眼恶性肿瘤患者凝血功能检测的临床意义

Meaning of the coagulative function in serum for eye malignant tumor diagnosis and evaluation

目的:探讨检测血浆中D-二聚体(D-D)、纤维蛋白原(Fib)及其降解产物(FDP)的水平在眼恶性肿瘤诊断和病情评估方面的应用及临床意义。方法:选择我院眼科确诊为眼恶性肿瘤患者67例(恶性肿瘤组),其中眼恶性肿瘤无转移组(44例)、眼恶性肿瘤转移组(23例);同期收治的眼良性肿瘤患者46例(良性肿瘤组);本院同期健康体检者30例(健康对照组)。测定血浆中D-D、Fib、FDP水平并进行比较。结果:眼恶性肿瘤患者血浆中D-D、Fib、FDP水平显著高于眼良性肿瘤组、健康对照组(P<0.05),其中恶性肿瘤转移组患者血浆中D-D、Fib、FDP水平又显著高于恶性肿瘤无转移组(P<0.05)。而眼良性肿瘤与健康对照组血浆中D-D、Fib、FDP水平差异无统计学意义(P>0.05)。各组D-D含量分布差异有统计学意义(P<0.05)。结论:血浆中D-D、Fib、FDP水平的检测对于眼良恶性肿瘤的判断及肿瘤的进展及预后有重要的临床意义。

AIM ： To explore the meaning of the level of D-dimer （D- D）, fibrinogen （Fib） and fibrin degradation products （FDP） in serum for eye malignant tumor diagnosis and evaluation. ~ METHODS： Sixty-seven patients with eye malignant tumor （malignant tumor group） in our hospital were selected, among which, 44 as malignant tumor without metastasis group, 23 as malignant tumor with metastasis group; 46 patients were selected with eye benign tumor （benign tumor group） during the same time period; 30 healthy people visited our hospital for regular physical examination was elected simultaneously as the healthy control group. The level of D-D, Fib and FDP were detected in serum. RESULTS： The D-D, Fib and FDP level in eye malignant tumor group was significantly higher than those in either the eye benign tumor group or the healthy control group （P〈 0.01 ）, malignant tumor with metastasis group had the significant higher level of D-D, Fib and FDP than those of malignant tumor without metastasis group （ P〈 0.05~）. There was no significant difference statistically between the eye benign tumor group and healthy control group of the serum level of D-D, Fib and FDP （P〉0.05）. There was significant difference of D-D level distribution among each group （ P〈0.05）. CONCLUSION- To detect the level of D-D, Fib and FDP in serum can help with differentiation the tumor from benign to malignancy, analysis the progression of tumor and prognosis.