核黄素/UVA诱导的角膜交联术治疗真菌性角膜溃疡

Riboflavin /UVA-induced corneal crosslinking in the treatment of fungal corneal ulceration

目的探讨核黄素/UVA诱导的角膜交联术治疗真菌性角膜溃疡的安全性和有效性。方法选取21例真菌性角膜溃疡患者行角膜交联术,术后继续局部用抗真菌药物,用裂隙灯观察角膜溃疡愈合情况,OCT观察角膜炎性信号变化。结果所有患者经过角膜交联术治疗后溃疡面积缩小,炎性信号强度减弱,其中5例1周内痊愈,11例2周内痊愈,4例1个月内痊愈,1例治疗无效,未见与交联相关并发症。结论角膜交联术联合抗真菌药物可以有效治疗真菌性角膜溃疡。

Objective To observe the safety and efficacy of riboflavin/UVA-induced corneal crosslinking in the treat- ment of fungal corneal ulceration. Methods 21 fungal ulceration patients underwent corneal crosslinking, followed by local anti-fungus medication. Slit-lamp and OCT were used to observe the healing process and the inflammation signal. Results The ulceration disappeared and inflammation signal decreased in all the patients after crosslinking treatment. Among them, 5 recovered within 1 week, 11 recovered within 2 weeks, 4 healed within 1 month and one case was non- effective. No corneal crosslinking-related complication was observed. Condusion Corneal crosslinking combined with local anti-fungus medication can effectively treat fungal corneal ulceration.