2型糖尿病合并非酒精性脂肪肝患者生化指标特征及胰岛素抵抗分析

Analysis of biochemical characteristic and insulin resistance in type 2 diabetes mellitus patients with non-alcoholic fatty liver

目的探讨2型糖尿病合并非酒精性脂肪肝与胰岛素抵抗的关系,为临床治疗提供依据。方法收集本院收治的80例2型糖尿病患者的临床资料,其中合并非酒精性脂肪性肝病(NAFLD)者52例设为NAFLD组,无NAFLD的38例设为无NAFLD组。比较2组患者的血脂、胰岛素等指标的情况。结果 NAFLD组患者的TG、TC以及LDL-C等指标均明显高于无NAFLD组,且其2hPG、Fins以及2hIns等指标均明显高于无NAFLD组,差异均具有统计学意义(P<0.05)。结论 2型糖尿病合并NAFLD患者存在显著的胰岛素抵抗,临床上应予以胰岛素增敏剂量相关药物进行治疗,值得临床参考。

Objective To investigate the relationship between type 2 diabetes mellitus with nonalcoholic fatty liver and insulin resistance, and provide the basis for clinical treatment. Methods The clinical data of 80 patients in our hospital with type 2 diabetes were collected and analyzed. Fifty-two patients were assigned to NAFLD group, and 38 patients non-NAFLD group. The indica- tors of lipids and insulin of the two groups were compared. Results The levels of TG, TC and LDL-C in NAFLD group were significantly higher than those in non-NAFLD group. The levels of 2hPG, fins and 2hIns were significantly higher than those in non-NAFLD group, and the differences were statistically significant （P 〈 0.05）. Conclusion Type 2 diabetes patients with nonalcoholic fatty liver has significant insulin resistance, thus clinical treatment should be insulin-sensitizing dose -related medicines, and it provides reference to clinical treatment.