期刊文献+

瑞舒伐他汀钙对急性脑梗死患者血脂和血清炎症因子的影响 被引量:11

下载PDF
导出
摘要 急性脑梗死是临床常见多发病,致残率和致死率较高,严重危害人体健康。患者就诊时多已错过溶栓治疗窗口期,因此治疗方案重点多集中在如何保护神经功能。他汀类药物可有效治疗脑梗死,不仅能调节血脂,还能减少炎性细胞因子分泌,稳定斑块,改善血管内皮功能,降低心脑血管疾病发生率。研究结果显示幢急性脑梗死伴随的局部炎性反应中炎性因子的变化起着关键作用。本研究探讨瑞舒伐他汀钙对急性脑梗死患者血脂、血清脂蛋白相关磷脂酶A(Lp—PLA2)和超敏C反应蛋白(hs-CRP)水平的影响,探讨瑞舒伐他汀钙治疗脑梗死的疗效及作用机制。
出处 《实用临床医药杂志》 CAS 2013年第17期89-90,共2页 Journal of Clinical Medicine in Practice
基金 中国高校医学期刊临床专项资金(11321108)
  • 相关文献

参考文献13

  • 1Schuetz C A, van Herick A, Alperin P, et al. Comparing the effectiveness of rosuvastatin and atorvastatin in preventing cardiovascular outcomes: estimates using the Archimedes model[J]. J Med Econ, 2012, 15(6): 1118.
  • 2Mayanagi K, Katakam P V, Gaspar T, et al. Acute treat- ment with rosuvastatin protects insulin resistant (C57BL/6J ob/ob) mice against transient cerebral ischemia[J]. J Cereb Blood Flow Metab, 2008, 28(12): 1927.
  • 3Gumbinger C, Sykora M, Diedler J, et al. Microalbuminuri- a: a potential prognostic marker for acute stmke[J]. Nerve- narzt, 2012, 83(10): 1357.
  • 4Jensen J K, Ueland T, Aukrust P, et al. Highly sensitive troponin T in patients with acute isehemic stroke [ J ]. Eur Neurol, 2012, 68(5): 287.
  • 5Shen C, Sun X, Wang H, et al. Association study of CRP gene and ischemic stroke in a Chinese Han population[J]. J Mol Neurosci, 2013, 49(3): 559.
  • 6Dewan K R, Rana P V. C-reactive protein and early mortali- ty in acute isehemic stroke [ J ]. Kathmandu Univ Med J (KUMJ), 2011, 9(36): 252.
  • 7Huang Y, Jing J, Zhao X Q, et al. High-sensitivity C-reac- tive protein is a strong risk factor for death after acute is- chemic stroke among Chinese[ J ]. CNS Neurosci Ther, 2012, 18(3): 261.
  • 8Tuttolomondo A, Di Raimondo D, Peeoraro R, et al. In- flamrnation in ischemie stroke subtypes[J]. Curr Pharm Des, 2012, 18(28): 4289.
  • 9Ddgado P, Chacon P, Penalba A, et al. Temporal profile and prognostic value of Lp-PLA2 mass and activity in the a- cute stroke setting [J ]. Atheroselerosis, 2012, 220 (2) : 532.
  • 10Elkind M S, Leon V, Moon Y P, et al. High-sensitivity C- reactive protein and lipoprotein-associated phospholipase A2 stability before and after stroke and myocardial infaretion[J]. Stroke, 2009, 40(10): 3233.

同被引文献103

  • 1邓志明.阿替普酶静脉溶栓治疗急性脑梗死临床疗效观察[J].世界最新医学信息文摘,2019,0(75):136-137. 被引量:3
  • 2陶恩学.老年急性脑梗死患者血浆Hcy水平变化与颈动脉硬化的相关性[J].中国老年学杂志,2014,34(8):2227-2228. 被引量:8
  • 3Hiroyuki Konya,Masayuki Miuchi,Kahori Satani,Satoshi Matsutani,Taku Tsunoda,Yuzo Yano,Tomoyuki Katsuno,Tomoya Hamaguchi,Jun-Ichiro Miyagawa,Mitsuyoshi Namba.Hepatocyte growth factor, a biomarker of macroangiopathy in diabetes mellitus[J].World Journal of Diabetes,2014,5(5):678-688. 被引量:5
  • 4邱明霞,覃小芬.浅谈对血管病变进行早期检测的方法及临床意义[J].当代医药论丛,2014,12(2):71-71. 被引量:2
  • 5Cohen JE, Leker RR. Endovascular treatment for acute ischemic, st roke[ J] . N Engl J ned,2013 ,368(25) :2432.
  • 6Dew an KR, Rana PV. C-reactive protein and early mortality in acute ischemic stroke [ J ]. Kathmandu Univ Med J ( KUMJ ) , 2011,9 ( 36 ) : 252.
  • 7Zhang R,Guo X,Guo L,et al.Prevalence and associated factors of obstructive sleep apnea in hospitalized patients with type 2 diabetes in Beijing,China 2[J].Journal of diabetes,2015,07(1):16-23.
  • 8Wu N,Li W,Lv Y,et al.Cardioprotective effects of low-dose combination therapy with rosuvastatin and fasudil in the isolated rat heart[J].Pharmazie,2014,69(9):704-708.
  • 9Sasao H,Fujiwara H,Murai H,et al.Does motor dysfunction after cerebral infarction impede the development of angina symptoms?A comparison of coronary angiographic findings in patients with and without prior cerebral infarction[J].Int Heart J,2013,54(1):1-6.
  • 10Kim E,Campbell S,Schueller O,et al.A small-molecule inhibitor of enterocytic microsomal triglyceride transfer protein,SLx-4090:biochemical,pharmacodynamic,pharmacokinetic,and safety profile[J].J Pharmacol Exp Ther,2011,337(3):775-785.

引证文献11

二级引证文献101

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部