神经节苷酯联合高压氧对急性脑梗死患者神经功能康复状态的影响研究

Influence of ganglioside combined with hyperbaric oxygen for rehabilitation of neurological function in patients with acute cerebral infarction

目的探讨神经节苷酯联合高压氧对急性脑梗死患者神经功能康复状态的影响。方法将本院2010年10月—2013年2月收诊的112例急性脑梗死患者随机分为对照组和观察组,每组56例。对照组采用基础治疗,观察组在此基础上加用神经节苷酯联合高压氧治疗。治疗前后分别采用美国国立卫生院神经功能缺损评分量表(NIHSS)、简易智能精神状态检查量表(MMSE)及日常生活活动量表(ADL)对2组患者的神经功能进行评估;统计治疗后2组的疗效差异。结果治疗28 d后,观察组NIHSS评分显著低于对照组,MMSE和ADL评分则显著高于对照组(P<0.05);观察组痊愈率和总有效率显著高于对照组(P<0.05)。结论神经节苷酯联合高压氧能有效促进急性脑梗死患者神经功能状态的康复。

Objective To observe the influence of ganglioside combined with hyperbaric oxygen on rehabilitation of neurological function in patients with acute cerebral infarction. Methods A total of 112 patients with cerebral infarction from October 2010 to February 2013 selected for this research from our hospital were randomly assigned to control group （ n = 56, routine treatment） and observation group （ n = 56, ganglioside combined with hyperbaric oxygen treatment）. NIHSS, MMSE and ADL were applied to assess the neurological functions of the two groups. Then the dif- ferences of clinical efficacy of the two groups were compared. Results After 28 - days treatment, NIHSS score of the observation group was markedly lower than that of the control group, but MMSE score and ADL score were higher than those of the control group, and the clinical effective- ness rate of the observation group was higher than that of the control group （P 〈 0.05）. Conclusion Ganglioside combined with hyperbaric oxygen can effectively can improve the rehabilitation of neurological function in patients with acute cerebral infarction.