肺癌患者术后早期应用低分子肝素对凝血功能的影响

Impact of early use of low molecular weight heparin on coagulation in lung cancer patients after operation

目的探讨低分子肝素对肺癌手术患者凝血功能的影响。方法选取2011年5月—2012年5月在本院胸外科诊治的肺癌术后患者49例,随机分为治疗组和对照组。对照组采用支持治疗,治疗组在对照组的基础上加用低分子肝素钙治疗。结果治疗组患者的深静脉血栓、肿瘤的进展情况及治疗前后D-二聚体、纤维蛋白原水平及深静脉血栓的发生情况明显优于对照组(P<0.05或P<0.01)。结论对肺癌术后患者早期应用低分子肝素治疗能有效预防静脉血栓的形成,延缓肿瘤的进展,延长患者的生存时间。

Objective To evaluate the impact of early use on coagulation in lung cancer patients after operation . Methods of low molecular weight heparin Totally 49 patients infected with lung infection after lung cancer radical mastectomy from May 2011 to May 2012 in thoracic surgery department of our hospital were selected and randomly assigned into treatment group and control group. The control group was treated with supporting treatment, and the treatment group was added with low molecular weight heparin calcium. Results The level of venous thrombosis and de- lay tumor progression and D- dimmer and fibrinogen in the treatment group was significant better than the control group （P 〈 0.05 or P 〈 0.01）. Conclusion Use of low molecular weight heparin at early period after lung cancer operation could effectively prevent venous thrombosis, delay tumor progression and prolong the survival time in patients.