某院2012年度药品不良反应报告的分析

Analysis of Adverse Drug Reactions in A Hospital during 2012

目的汇总分析2012年度ADR报告，保障患者用药安全，促进我院临床合理用药。方法统计我院2012年1～12月份404例ADR，从患者年龄、性别、给药途径、临床表现、严重ADR、ADR前10位药品进行统计分析。结果404例报告中，〉60岁患者的ADR发生率较高；静脉滴注引起的ADR365例，占90．35％；ADR类型主要为皮肤及其附件损害112例，占27．72％；新的、严重的ADR105例，占25．99％。结论药品不良反应的监测需要关注症状，更要关注生化检测和影像学的客观指标，不断提高不良反应报告质量和数量，不断提高临床合理用药水平。

Objective To summarize the analysis of ADRs reported in our hospital during 2012, ensure the patient safety and promote the rational clinical use of drugs in our hospital, Methods 404 cases of ADRs were analyzed in respect of the age distribution of patients, gentler, route of administration, clinical manifestation, serious adverse reactions, the top 10 drugs of ADRs, and so on. Results ADRs incidence of patients over 60 ages was higher, ADRs were mainly caused by intravenous administration （90.35%）, 112 cases of skin and its accessories damage occupied 27.72%, and 105 new, serious ADRs accounted for 25.99%. Conclusions To improve the clinical rational administration, monitoring of ADRs needs pay close attention to not only the symptom, but also the biochemical detection and imaging objective indexes for the quality and quantity of ADRs,.