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类风湿关节炎引起血小板增多 被引量:4

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摘要 类风湿关节炎是一种以慢性侵蚀性关节病为变现的自身免疫性疾病。其除关节病变外,常可累及其他全身多个系统。累及血液系统时多可引起血小板增多。我们对符合2009年类风湿关节炎诊断标准并明确诊断为类风湿关节炎患者50例进行观察,将其血小板、ESR、CRP、RHF在治疗前、治疗后1个月、治疗后2个月、治疗后3个月及6个月的变化进行了统计发现其ESR、CRP在风湿活动时升高者达100%,RHF阳性升高率达77%,而PLT升高率达71%,而随着病情的控制后,PLT随着ESR、RHF逐渐下降恢复正常。这说明PLT的增多常跟ESR、CRP、RHF成正相关,这间接地说明血小板也是一个反应疾病活动的炎性指标。而引起血小板身高跟白细胞介素-11、白细胞介素-6、TNF-α、IL-1b、促血小板生成素(TPO)、白血病抑制因子(LIF)等细胞因子有密切的关系。
作者 张渝
出处 《中国医药指南》 2013年第27期594-595,共2页 Guide of China Medicine
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