低分子肝素钙治疗短暂性脑缺血发作的疗效观察

Observe the Low Molecular Weight Heparin Treatment of Transient Ischemic Attack Efficacy

目的探讨低分子肝素钙治疗短暂性脑缺血发作(TIA)的临床效果。方法 60例短暂性脑缺血发作患者随机分为治疗组和对照组,每组30例。两组均给予促进脑部血液循环,调节血脂,营养神经等基础治疗。治疗组在基础治疗上加用低分子肝素钙5000U,腹壁皮下注射,12h 1次,连用10d。对照组在基础治疗上加用低分子右旋糖酐500mL,静脉滴注,1次/天,疗程10d。结果疗程结束后短暂性脑缺血发作控制率治疗组和对照组分别为96.67%(29/30)和70%(21/30)。随诊6个月治疗组复发率低于对照组,差异有统计学意义(P<0.05),两组患者在治疗期间及治疗后均未发现明显不良反应。结论低分子肝素钙对短暂性脑缺血发作近远期疗效均显著,复发率低,且未见明显的不良反应,值得临床推广。

Objective To investigate clinical effect of the low molecular heparin calcium in the treatment of transient ischemic attack（TIA）. Method 60 patients having transient ischemia attack are divided into a treatment group （A） and a placebo group （B）, 30 patients each. Some basic treatments are implicated to both of the groups, in order to stimulate the blood circulation of brain, regulate blood lipids and improve nerve-nurturing. Besides the basic treatments, group A is given low molecular heparin calcium 5000U by Abdominal subcutaneous injection： once every 12 hours for ten days. Besides the basic treatment, group B is given low molecular dextran 500mL： once every day for ten days. Result After six months of clinic follow-up, group A recurrence rate is lower than group B and the difference is statistically significant （P〈0.05）. No obvious adverse reactions are observed in the two groups during the treatment course. Conclusion Low molecular heparin calcium has significant effect against transient ischemia attack for both short term and long term treatment; the recurrence rate is low and no obvious adverse and reactions are observed. It is suitable for clinical use.