多西他赛联合奥沙利铂在晚期胃癌治疗中的临床效果分析

Analysis on the Clinical Efficacy of Docetaxol and Oxaliplatin Combination in Treatment of Advanced Gastric Cancer

目的探索多西他赛联合奥沙利铂在高原地区晚期胃癌治疗中的临床应用价值。方法 75例晚期胃癌,随机抽样38例进入研究组,其余37例为对照组,分别给予DO方案(多西他赛联合奥沙利铂)和DCF方案(多西他赛+氟尿嘧啶+顺铂)化疗。结果 DO组和DCF组的有效率分别为44.73%和40.54%,两组间差异无统计学意义(P>0.05)。DO组临床受益反应有效率81.6%,DCF组组临床受益反应有效率75.7%。观察组和对照组不良反应情况中骨髓抑制,腹泻,脱发,关节酸痛及口腔黏膜炎的发生率差异无统计学意义,但DO方案胃肠道反应较DCF方案轻,而神经毒性较DCF方案明显。结论 DO方案治疗晚期胃癌疗效确切,胃肠道反应等不良反应轻,值得临床中推广。

Objective To observe the clinical application value of DO regimen in the treatment of advanced gastric carcinoma.Methods 75 patients with advanced gastric carcinoma,DO and DCF regimen was used.The toxieities of the two groups were evaluated after treatment.Results The response rates of the DO group and the DCF group were 44.73%and 40.54%,respectively;there was no significant difference between the two groups（P〉0.05）.The response rates of the DO group and the DCF group were 81.6%and 75.7%,respectively.The toxicities of the two groups were leucopenia,gastrointestinal reaction,arthr algia, fatigue,alopecia.Conelusion The response rate of DO regimen for patients with advanced gastric carcinoma was similar to DCF regimen regimen, and the toxicities are all tolerable,but the gastrointestinal reaction of DO regimen was lesser serious than DCF regimen.