硫酸镁对新生儿胎粪吸入综合征(MAS)的治疗作用

Therapeutic Effects of Ambroxol on Neonatal Meconium Aspiration Syndrome

目的探索应用硫酸镁治疗新生儿胎粪吸入综合征(MAS)的临床疗效。方法将68例新生儿胎粪吸入综合征患者分为34例对照组,采用常规综合治疗;34例治疗组,采用在常规综合治疗的基础上使用硫酸镁给药治疗,观察对比患者的呼吸功能的恢复时间、住院时间和病死率以及并发症心、肝、肾功能的损伤情况。结果采用在常规综合治疗的基础上使用硫酸镁给药治疗的治疗组患者呼吸功能的恢复时间为5.90±1.40,住院时间为11.90±1.10,病死率为5.9%;对照组呼吸功能的恢复时间为8.10±1.6,住院时间为15.10±1.40,病死率为17.6%,两组差异具有统计学意义(P<0.05)。结论采用在常规综合治疗的基础上使用硫酸镁给药治疗的治疗组患者,在呼吸功能的恢复时间为、住院时间和病死率以及并发症心、肝、肾功能的损伤情况等方面均优于采用常规综合治疗,值得在临床治疗上推广。

Objective To explore the application of magnesium sulfate in the treatment of neonatal meconium aspiration syndrome （MAS） clinical curative effect. Method 68 cases of neonatal meconium aspiration syndrome were divided into 34 cases of the control group, using the routine treatment; 34 cases in treatment group, the magnesium sulfate on the basis of routine treatment for drug treatment, observation of respiratory function compared with recovery of injury time, hospitalization time and mortality and complications of heart, liver, kidney function. Result Recovery time using magnesium sulfate on the basis of routine treatment medicine treatment to the patients in the treatment group was 5.90± 1.40 respiratory function, hospitalization time was 11.90± 1.10, the mortality rate was 5.9%; the control group of respiratory function recovery time was 8,10±1.6, duration of hospitalization was 15.10±1.40, the mortality rate was 17.6%, two groups the difference was statistically significant （P〈0.05）. Conclusion Patients treated with magnesium sulfate on the basis of routine treatment medicine treatment to use, in the recovery time of respiratory function, hospitalization time and mortality and complications of heart, liver, renal injury is superior to that using the routine treatment, worthy of promotion in clinical treatment