代谢肿瘤体积对非小细胞肺癌术后复发的预测价值

Prognostic Value of Metabolic Tumor Volume for Post-Operative Recurrence in Patients with Non-Small Cell Lung Cancer

目的评估代谢肿瘤体积(MTV)对非小细胞肺癌患者术后的复发预测情况。方法回顾性分析112例行完全性切除术的非小细胞肺癌患者,术前均行18F-FDG PET/CT检查,术后进行追踪随访。应用ROC曲线分析MTV对复发的预测性能。应用Cox比例风险回归模型进行多因素分析探讨复发与相关危险因素之间的关系。结果 ROC曲线比较表明,MTV2.5较SUV max有更好的预测复发的性能。MTV2.5较小的患者具有更高的无复发生存率。多因素分析显示MTV2.5和TNM分期是影响复发的独立危险因素。结论 MTV是判断非小细胞肺癌术后复发的重要预后因素。

Objective To evaluate the usefulness of metabolic tumor volume（MTV） in predicting recurrence in surgically re-sected non-small-cell lung cancer（NSCLC） patients. Methods 112 patients with complete resection of non-small cell lung canc-er were retrospective analyzed. All the patients underwent 18F-FDG PET/CT examination before surgery. A follow-up was conduc-ted after surgery. We used receiver-operating characteristic （ROC） curve analysis to test the predictive performance of MTV for recurrence. Muhivariate Cox regression was used to test the relationship of recurrence-free probability to various factors. Results Comparison ROC curve showed that MTV had better predictive performance than SUVmax for recurrence. Patients with smaller MTV2.5 showed longer recurrence-free survival. Multivariate analysis showed that MTV2.5 and TNM stage were independent risk factors for recurrence. Conclusion MTV was an important prognostic factor for recurrence in NSCLC patients who have received surgical treatment.