胆红素与急性脑梗死的关系

Research of Correlation between Serum Bilirubin Level and Acute Cerebral Infarction

目的探讨血清总胆红素、直接胆红素及间接胆红素水平与急性脑梗死的关系。方法选取蚌埠医学院第二附属医院2012年10月-2013年7月住院的脑梗死患者57例为脑梗死组,其中男性38例,女性19例,同期体检中心22例健康人为对照组,其中男性11例,女性11例,所有受检者均禁食12 h以上,清晨空腹抽取静脉血,采用全自动生化仪测定血清总胆红素、直接胆红素及间接胆红素水平,并进行相关统计学分析。结果①脑梗死组与对照组的年龄、性别构成、高血压病史、糖尿病史之间比较差异均无统计学意义(P>0.05);②脑梗死组患者血清总胆红素、直接胆红素及间接胆红素水平低于对照组(P<0.05)。结论低水平的血清总胆红素、直接胆红素及间接胆红素在脑梗死发生和发展过程中可能扮演十分重要的角色。

Objective To evaluate the association of the serum level of total bilirubin, direct bilirubin and indirect bilirubin and acute cerebral infarction. Methods 57 cases of acute cerebral infarction inpatients of our hospital were set as cerebral in-farction group, of which 38 cases were male, 19 cases were women and 22 healthy people in our hospital physical check-up center as control group, of which 11 cases were male, 11 cases were female, they were selected from October 2012 to July 2013. All sub-jects were drawn vein blood after fasting 12 hours. Serum concentration of total bilirubin, direct bilirubin and indirect bilirubin were measured by automatic biochemical analyzer. Results ①The differences of the two groups about age, sex ratio, hypertension and diabetes were not statistically significant（ P 〉 0.05 ） ;②The serum level of total bilirubin, direct bilirubin and indirect biliru-bin of acute cerebral infarction group were found significantly lower than those of the control group （ P 〈 0.05 ）. Conclusion Low level of total bilirubin, direct bilirubin and indirect bilirubin may play a very important role in the occurrence and development of acute cerebral infarction.