血浆致动脉硬化指数与高血压晨峰相关性分析

Analysis of Relationship between Morning Blood Pressure Surge and Atherogenic Index of Plasma in Hypertensive Patients

目的探讨高血压患者的晨峰血压与血浆致动脉硬化指数的相关性。方法 107例高血压患者为观察组,109例健康者为对照组,24 h动态血压监测,观察血压晨峰,测定总胆固醇、甘油三酯、高密度脂蛋白胆固醇,计算log[TG/HDL-C]为血浆致动脉硬化指数。结果高血压组与对照组的晨峰血压分别为(42.08±6.33)mm Hg、(22.52±10.73)mm Hg(P<0.01);观察组和对照组的血浆致动脉硬化指数分别为0.32±0.28、-0.19±0.19(P<0.01)。高血压组血压晨峰与血浆致动脉硬化指数之间呈中度正相关(r为0.42,P<0.01)。结论高血压晨峰现象与血浆致动脉硬化指数存在一定联系,可以作为血浆脂蛋白之动脉硬化形成性的一种标志物,也是高血压患者临床观察中有实用价值的重要参数。

Objective To approach the relationship between morning blood pressure surge （MBPS）and atherogenic index of plasma（AlP） in hypertensive patients. Methods A total of 107 hypertensive patients were selected as objective group and 109 cases of healthy people as control group. The ambulatory blood pressure monitoring（ABPM） was done; MBPS was observed; the levels of total cholesterol, triglyeride and high density lipoprotein cholesterol were tested. The atherogenic index of plasma was cal-culated by log [ TG/HDL-C ]. Results The objective group and control group data were as follow. MBPS ： （ 42.08 ± 6.33 ） mm Hg and （ 22.52 ± 10.73 ） mm Hg（ P 〈 0. 01 ） ; AlP ：0.32 ± 0.28 and - 0.19 ± 0.19 （ P 〈 0.01 ）. There was a middle positive correla-tion（ r = 0.42 ,P 〈 0.01 ）between MBPS and AIP in hypertensive patients. Conclusion There is a relation between MBPS and AIP in hypertensive patients. AlP could be used as a marker of plasma atherogenicity and could be used as a useful and an impor-tant parameter of clinical observation in hvDertensive patients.