血清LDL-C均相法与Friedewald公式计算法相关性分析

Correlative Analysis of Results of Low Density Lipoprotein Cholesterol by Homogeneous Methods and Friedewald Formula Calculation

目的比较匀相法直接测定血清低密度脂蛋白胆固醇（LDL—C）的值与Friedewald公式法计算所得结果之间的相关性。方法对2011年月-2011年9月6493例健康体检者相关资料进行统计分析，对TC、TG、LDL—C同时运用F公式计算LDL．C值，并对测定值和计算值两组数据进行统计学处理。结果按TG≤1．70mmol／L、1．71—2．70mmol／L、2．71～3．70mm01／L、3．71—4．52mmol／L、〉4．52mmol／L分为5组，匀相测定法与F公式法的相关性系数分别为0．915、0．903、0．972、0．941。当TG〉4．52mmol／L时其结果分别为（2．17±O．37）mmolfL及（1．51±0．78）mmol／L，r=0．536。两组间差异有统计学意义（P〈0．05）。按TC≤6．2mm01／L和TC〉6．2mmol／L分为2组，其相关性系数分别为0．853及0．457（P〈0．05）。结论TG水平≤4．52mmoL／L时，F公式必须符合Friedewald假设条件，其计算值可作为参考。直接法能较好的反映出LDL-C的含量。

Objective To analyze the correlation of the results of low density lipoprotein cholesterol（LDL-C） detected by di-rect determination（ Homogeneous Methods） and Friedewald formula calculation. Methods Total 6493 health people were in-volved in this study from March to September in 2011. TG, TC and LDL-C in serum were examined by direct determination and Friedewald formula calculation. Data were statistically analyzed. Results All patients divided into group A （ less than 1.70 mmol/L） ,group B（1.71 to 2.70 retool/L） ,group C（2.71 to 3.70 retool/L） ,group D（3.71 to 4.52 mmol/L） and group E （more than 4.52 retool/L） based on the levels of triglyeride （TG）. The correlation coefficient between the two methods was 0. 915,0. 903,0. 972 and 0. 941 in group A ,B ,C and D ,respectively. When TG was more than 4.52 mmol/L,the levels of LDL-C by direct determination and Friedewald formula calculation were （ 2.17 ± 0.37 ） mmol/L and （ 1.51 ± 0.78 ） retool/L, respec-tively,r = 0. 536, the difference was significant. In the group E, the patients were divided into group Ⅰ （ 〈 6.2 retool/L） and group Ⅱ （ 〉 6.2 mmol/L） based on total cholesterol ;the correlation coefficient between the two methods was 0.853 in group I and 0. 457 in group Ⅱ （ P 〈 0.05 ）. Conclusion When TG is less than 4.52 mmol/L, Ffiedewald formula calculation results can be used as a reference when the determination according to the assumed conditions;The direct determination（ Homogeneous Meth- ods） can well reveal the level of LDL-C.