奥曲肽治疗普胸术后胸腔渗液疗效观察

The efficacy of octreotide in the treatment of pleural effusion after thoracic surgery

目的观察奥曲肽治疗普胸术后胸腔渗液的疗效。方法将普胸术后胸腔渗液76例随机分为观察组44例和对照组32例,对照组仅给予常规治疗,观察组在常规治疗同时皮下注射奥曲肽0.1 mg,1次/8 h。比较两组治疗有效率及用药前后胸液量变化。结果观察组有效率为88.6%,发生不良反应1例(2.27%),对照组有效率28.1%,两组疗效比较有显著差异(P<0.01)。用药前两组患者胸液量比较无显著差异(P>0.05),用药后第3天开始胸液量比较有显著差异(P<0.01)。结论奥曲肽应用于治疗普胸术后胸腔渗液安全有效。

Objective To monitor the efficacy of octreotide in the treatment of pleural effusion after thoracic surgery. Meth- ods The treatment group consisted of 44 patients with pleural effusion fitting the inclusion criteria. Subcutaneously injected Octreotide 0.1 mg was administered every 8 hours in additional to basic treatment. The control group consisted of 32 patients selected during the same period who were given only basic treatment. Comparisons were made between the two groups for differences in treatment efficacy and in quantity of drainage as measured before and after the administration of pharmacotherapy. Results The effective rate of treatment in the treatment group was 88.6%. Only 1 side effect was observed （2.27%）. The effective rate of treatment in the control group was 28.1%. The difference in effective rates between the two groups was statistically significant（ P 〈 0.01 ）. From the third day after treat- ment,a statistically significant difference was observed between the two groups in terms of the amount of pleural effusion （P 〈0.01 ） , while no difference in pleural effusion was seen before treatment between two groups （ P 〉 0.05 ）. Conclusion Oetreotide is an effec- tive, safe, and simple option for the treatment of pleural effusion after thoracic surgery.