血清淀粉酶、血脂肪酶、尿淀粉酶、尿胰蛋白酶原-Ⅱ检测在急性胰腺炎早期诊断中的临床价值

Clinical values of detection of serum amy /lipase and urine amy / trypsinogen Ⅱ in diagnosis of acute pancreatic diseases

目的探讨临床实验室检测尿胰蛋白酶原-Ⅱ(U-Try-Ⅱ)、血清淀粉酶(AMY)、血脂肪酶(LIPA)、尿淀粉酶(UAMY)在急性胰腺炎(acute pancreatitis,AP)早期诊断中的临床价值。方法对我院100例急腹症患者进行U-Try-Ⅱ、AMY、LIPA、UAMY联合检测,比较其对急性胰腺炎的敏感性和特异性,并对四种方法的优缺点作出分析评价。结果 AP患者U-TryII、AMY、LIPA及UAMY阳性检出率均明显高于非AP患者,差异有统计学意义(P<0.05)。U-Try-II诊断AP的特异性和敏感性均明显高于AMY、LIPA及UAMY。结论 U-Try-Ⅱ尿胰蛋白酶原-Ⅱ可作为AP的早期检测筛查指标,其敏感性和特异性均优于其他三种方法。

Objective To explore the clinical significance of urine trypsinogen-Ⅱ （U-Try-Ⅱ）, serum amylase （AMY）, serum li-pase （ LIPA）, and urine amylase （UAMY） in early diagnosis of acute pancreatitis. Methods One hundred cases with acute pancreatitis in our hospital were included in the study. The sensitivity and specificity of combined detections of U-Try-Ⅱ, AMY, LIPA and UAMY for diagnosis of acute pancreatitis were estimated, and the advantages and disadvantages of the methods were evaluated. Results Of 61 a-cute pancreatitis cases,58 cases were U-Try-Ⅱ positive,41 cases were AMY positive,43 cases were LIPA positive, and 26 cases were UAMY positive. The diagnostic sensitivity and specificity of U-Try-Ⅱ was significantly higher than that of LIPA, AMY or UAMY （ P 〉 0. 05）. Conclusion U-Try-Ⅱ can be used as an early screening indicator,which has high sensitivity and specificity.