雾化吸入布地奈德治疗小儿急性感染性喉炎疗效观察

The Clinical Observation of Budesonide Aerosol Inhalation in Acute Infectious Laryngitis in Children

目的:探讨雾化吸入布地奈德治疗小儿急性感染性喉炎的疗效。方法:将2011年1月至2012年12月来医院就诊的小儿急性感染性喉炎患106例儿随机分为A、B两大组:A组(46例)再分为A1、A2两组,每组23例,B组(60例)再分为B1、B2两组,每30例;A组为轻度症状病人,其中A1组患儿予雾化吸入布地奈德+常规治疗,A2组患儿予静滴地塞米松+常规治疗;B组患儿为中重度症状病人,其中B1组患儿予雾化吸入布地奈德+静滴地塞米松+常规治疗,B2组患儿予静滴地塞米松+常规治疗。结果:A1、A2两组患儿临床治疗效果相当,统计学上无统计学差异(P>0.05)。B1组患儿较B2组患儿临床症状消失时间明显缩短,统计学上有统计学差异(P<0.05)。结论:雾化吸入布地奈德治疗小儿急性感染性喉炎疗效肯定,安全副作用小,值得临床推广应用。

Objective:To observe the curative effect of budesonide aerosol inhalation in acute infectious laryngitis in children in order to guide the clinical treatment.Methods:Total 106cases of acute infectious laryngitis in children in the Jiangning Affiliated Hospital of Nanjing Medical University from 2011to 2012were analyzed in this study.The children were divided into two groups based on the states of illness.The 46mild children were in group A and 60severe children were in group B.Then,the children in group A or group B were equally subdivided into group A1and A2(23cases in each),or B1and B2(30cases in each).The children in group A1and B1were treated with budesonide aerosol inhalation and conventional therapy,and additionally,the children in group B1 were treated with intravenous dexamethasone.The children in group A2and B2were treated with intravenous dexamethasone and conventional therapy.Results:The reduction time of clinical symptoms in the children of group B1was significantly shorter than the children of group B2(P<0.05). There was no significant difference of clinical effect between group A1and A2(P>0.05).Conclusion:The budesonide aerosol inhalation is an effective,and safe treatment in acute infectious laryngitis in children and worthy of being widely applied in clinic.