低分子肝素联合硫酸镁在妊娠期高血压疾病中的应用

Application of low molecular weight heparin combined with magnesium sulfate in hypertensiue disorder complicating pregnancy

目的探讨低分子肝素联合硫酸镁在妊娠期高血压疾病患者中的应用效果。方法将80例患者随机分为对照组和观察组,每组40例,对照组给予硫酸镁静脉滴注,治疗的同时加用拉贝洛尔;观察组在对照组的治疗基础上给予低分子肝素,治疗3 d,对两组患者治疗前后血小板计数、凝血酶原时间以及D-二聚体的测定结果进行观察,并对两组患者产后2 h出血量进行测定。结果观察组和对照组患者产后2 h出血量分别为(350.6±119.5)ml和(353.4±120.3)ml,差异无统计学意义(P>0.05)。D-二聚体水平较对照组治疗后有明显降低,P<0.05。血小板计数和凝血酶原时间治疗前后差异无统计学意义(P>0.05)。结论低分子肝素联合硫酸镁治疗妊娠期高血压疾病可有效降低D-二聚体水平,安全性较高,不会增加出血的危险。

Objective To investigate the low molecular heparin combined with magnesium sulfate ap- plication effect in patients with hypertensive disorder complicating pregnancy. Methods 80 patients were ran- domly divided into control group and observation group, 40 cases in each group, the control group was given in- travenous injection of magnesium sulfate, treatment with labetalol treatment; observation group were based on the given low molecular heparin, treatment for 3 D, in two groups before and after treatment the platelet count, prothrombin time two and D- dimer were measured and the results are observed, and the two groups of patients with postpartum hemorrhage were measured for 2 hours. Results the observation group and the control group of patients with postpartum hemorrhage 2 hours were （350. 6 ＋ 119.5） ml and （353.4 ＋ 120. 3） ml, the differ- ences were not statistically significant, P 〉 0. 05. The two D- dimer level than the control group after treatment decreased significantly, P 〈 0. 05. No significant difference in platelet count and prothrombin time before and after the treatment, P 〉 0.05. Conclusion Low molecular heparin combined with magnesium sulfate in the treatment of hypertensive disorders in pregnancy can effectively reduce the D- two level of D-dimer, high securi- ty, decreased bleeding risk.