血清IL-6、IL-10及IFN-α水平对首发抑郁患者双侧海马区细胞代谢影响的磁共振波谱研究

The 1H-MRS research of cell metabolism in the first episode depression affected by blood IL-6、IL-10及 IFN-α in bilateral hippocampus

目的利用磁共振波谱技术探究IL-6、IL-10及IFN-α在抑郁症发病过程中对双侧海马区细胞代谢的影响。方法利用1H-MRS分别检测20例首发抑郁症患者及20名健康志愿者双侧海马的各代谢指标,采集静脉血并检测血清中IL-6、IL-10及IFN-α水平,将波谱检测的各代谢指标与血清中IL-6、IL-10及IFN-α水平进行相关性分析。结果相对于正常组,首发抑郁组患者左侧海马的Glx/Cr及NAA/Cr显示下降,而Cho/Cr显示升高,MI/Cr变化不明显;右侧海马仅仅出现Glx/Cr的下降,其余指标未见有统计学意义的升高。相对于正常组,首发抑郁组患者血清中IL-6及IFN-α水平升高,并有统计学意义,IL-10水平变化不明显。双侧海马的Glx/Cr水平与IL-6、IFN-α水平呈明显负相关;左侧海马的NAA/Cr水平与IL-6、IFN-α水平亦呈显著负相关,左侧海马的Cho/Cr水平与IL-6、IFN-α水平成明显正相关。结论首发抑郁症患者血清中的炎症因子水平会出现不同程度的变化,这些变化可能影响了双侧海马的神经细胞代谢,可能是首发抑郁症发病机制的一种潜在因素。

Objective To explore the cell metabolism of the bilateral hippocampus effected by blood IL-6,IL-10 and IFN-αin the development of the depression by 1 H-MRS. Methods Using Proton magnetic resonance spectroscopy and ana- lyzing technology 1 H-MRS to detect muhiple metabolic indices of the bilateral hippocampus of 20 first episode depression patients and 20 healthy persons, and detecting the levels of IL-6,IL-10 and IFN-ot in blood serum, finally, analyzing the cor- relation between them. Results Compared with the healthy group, the values of Glx/Cr and NAA/Cr were reduced whereas the value of Cho/Cr was increased in left hippoeampus, only the values of Glx/Cr were reduced in right hippocampus, the other metabolic indices changed unobvious;the depressive group has the significantly higher levels of IL-6, IFN-α in blood serum,but no significant difference was found in the IL-10 level in blood serum. The Glx/Cr of bilateral hippocampus level was negatively correlated to the IL-6 and IFN-α level in blood serum. The NAA/Cr of left hippocampus level was negatively correlated to the IL-6 and IFN-cdevel in blood serum. The Cho/Cr of left hippocampus level was negatively correlated to the IL-6 and IFN-α level in blood serum. Conclusion The levels of the inflammatory cytokines in the first episode depression blood serum changes.it may affect the cell metabolism of the bilateral hippocampus and lead to depression.