影响基底动脉狭窄常见危险因素的临床分析

Clinical analysis of common risk factors of basilar artery stenosis

目的 探讨影响基底动脉狭窄的常见临床危险因素.方法 收集2009年1月至2010年1月我院住院有后循环缺血症状并行脑血管造影的患者64例.根据脑血管造影结果将资料分为基底动脉狭窄组（39例）和非狭窄组（25例）,以单因素及多因素方法分析其常见临床危险因素.结果 单因素分析发现：患者的年龄（t=3.61,P=0.01）、血清同型半胱氨酸（Hcy）水平（t=2.571,P=0.013）及椎动脉狭窄（x2=8.34,P=0.004）都是基底动脉狭窄的影响因素,而高血压、糖尿病、高血脂、吸烟等指标未达统计学差异；二项分类Logistic回归发现：年龄（OR=1.17,P=0.007）、血清Hcy水平升高（OR=1.47,P=0.040）及椎动脉狭窄（OR=5.45,P=0.01）是影响基底动脉狭窄的主要危险因素,余指标差异无统计学意义.结论 年龄、椎动脉狭窄及血清Hcy水平升高是影响基底动脉狭窄的主要临床危险因素.

Objective To investigate common clinical risk factors of basilar artery stenosis.Methods 64 patients with ischemic symptoms of posterior circulation undergoing cerebral angiography were collected from January 2009 to January 2010.They were divided into basilar artery stenosis group （39 cases） and non stenosis group （25 cases） according to angiographic results.Univariate and multivariate methods were used to analyze common clinical risk factors of basilar artery stenosis.Results Univariate statistics showed that basilar artery stenosis was related to high age （t=3.61,P=0.01）,high serum homocysteine level （t=2.571,P=0.013） and vertebral artery stenosis （x 2=8.34,P=0.004）,whereas high blood pressure,diabetes,high blood lipid and smoking didn＇ t reach statistical differences between two groups.Bivariate logistic regression showed that high age （OR=1.17,P=0.007）,high serum homocysteine level （0R=1.47,P=0.040） and vertebral artery stenosis （OR=5.45,P=0.01） were major risk factors of basilar artery stenosis.Conclusion Age,vertebral artery stenosis and high serum homocysteine level are major clinical risk factors of basilar artery stenosis.