PD-1/PD-Ls与免疫相关疾病的研究进展

PD-1/PD-Ls on the immune-related diseases of research progress

PD-1是CD28分子家族的成员之一,表达于多种免疫细胞表面,通过PD-L1或PD-L2表达负性调控信号。PD-1的免疫受体络氨酸转化基序(ITSM)磷酸化后可以募集SHP2降低PLCg2,PI3K,VAV和ERK1/2的激活,进而调控免疫细胞的激活和免疫耐受。PD-1与其配体的相互作用在自身免疫性疾病,感染性疾病和肿瘤等方面均起重要作用。PD-1与其配体的生理学作用表明调控PD-1途径是治疗人类多种疾病的一个靶向目标。本文总结了PD-1与其配体的免疫调控功能以及在相关性疾病中的临床意义。

PD-1 is a member of the CD28 family of molecules expressed on the surface of a variety of immune cells, through the PD-L1 or PD-L2 expression of negative regulatory signals. The phosphorylated immune receptor tyrosine conversion motif （ITSM） of PD-1 can raise SHP2 which could attenuate the activation of PLCg2, PI3K, VAV and ERK1/2, and then PD-1 reg-ulates the activation of immune cell and immune tolerance. PD-1 and its ligands interactions play crucial roles in autoimmune diseases, infectious diseases and tumors. The biological role of PD-1 and its ligands suggest that manipulated PD-1 pathway may be a target for treating many human diseases. In this review, we summarize the PD-1 and its ligands ranging from the immune regulation function to the related diseases of clinical significance.