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微阵列芯片技术在儿童畸形中的应用

Application of microarray chip technology in children in malformation
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摘要 微阵列芯片技术是生命科学和信息工程相结合的高科技结晶,是高效率的核酸杂交分析技术,以其连续化、微型化、自动化等优势在基因组结构和功能的研究上起着重要作用。目前该技术主要应用于基因组功能研究、临床诊断及预后判断、新药开发及药物筛选等方面,在生命科学的许多领域得到广泛应用,并且扮演着重要角色。本文将对该技术应用于儿童畸形方面做一综述。 Microarray technology is a high-tech crystallization of life science and information engineering together, is a nu-cleic acid hybridization efficiency analysis technology, plays an important role in the continuous, miniaturization, automation and other advantages of the genome structure and function. The present study, the technology is mainly applied in genome function in clinical diagnosis and prognosis, the development of new drugs and drug screening and so on, has been widely ap-plied in many fields of life science, and plays an important role. In this paper, the application of this technology on deformi-ties in children is reviewed.
作者 黄少玲 吴曙粤 魏谋
机构地区 广西医科大学附属南宁市第一人民医院儿科 广州市妇女儿童医疗中心NICU
出处 《中国医药导报》 CAS 2013年第30期39-41,共3页 China Medical Herald
关键词 微阵列芯片技术 儿童畸形 应用 Microarray chip technology Deformities in children Application
分类号 R789 [医药卫生—口腔医学]
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参考文献20

  • 1Sehena M, Shalon D, Davis RW, et al. Quantitative monitoring of gene expression pattem with a complementary DNA mi- croarray [J]. Science, 1995,270 : 467-470.
  • 2裘敏燕,李瑶,谢毅,毛裕民.基因芯片技术及其应用[J].第二军医大学学报,2001,22(6):534-537. 被引量：19
  • 3Shoemaker DD, Schadt EE,Armour CD,et al. Experimental an- notation of the human genome using micmarray technology [J]. Nature, 2001,409 : 922-927.
  • 4Brown NL,Knott L,Halligan E,et al. Microarray analysis of murine palatogenesis:temporal expression of genes during normal palate development [J]. Dev Growth Differ, 2003,45 (2) : 153-165.
  • 5沈璐,丛蔚,王如,肖晶.维甲酸诱导腭裂相关wnt和成纤维细胞生长因子配体表达的动态变化[J].华西口腔医学杂志,2011,29(1):62-65. 被引量：5
  • 6孙静,刘必成.基因芯片技术及其在肾脏病学研究中的应用[J].东南大学学报（医学版）,2002,21(2):194-198. 被引量：1
  • 7Nagasawa Y,Takenaka M, Kaimori J,et al. Rapid and diversechanges of gene expression in the kidneys of protein-overload proteinuria mice detected by microarray analysis [J]. Nephrol Dial Transplant, 2001,16 (5) : 923-931.
  • 8Alcorta DA,Prakash K,Waga I,et al. Future molecular approach- es to the diagnosis and treatment of glomerular disease [J]. Semin Nephrol, 2000,20 ( 1 ) : 20-31.
  • 9文毅,谭端军,朱庆磊.基因探针与表达序列标签微阵列技术在心血管疾病分子研究中的应用[J].中华老年多器官疾病杂,2004,3(2):142-145.
  • 10Taylar LA,Carthy CM, Decheng Y,et al. Host gene regula- tion during Coxsackie virus B3 infection in mice:assessment by microarrays [J]. Circ Res,2000,87:328-334.

二级参考文献86

  • 1van Amerongen R, Nusse R. Towards an integrated view of Wnt signaling in development[J]. Development, 2009, 136 (19) :3205- 3214.
  • 2Nie X, Luukko K, Kettunen P. FGF signalling in craniofacial development and developmental disorders[J]. Oral Dis, 2006, 12 (2) : 102-111.
  • 3Niemarm S, Zhao C, Pascu F, et al. Homozygous WNT3 muta- tion causes tetra-amelia in a large consanguineous family[J]. Am J Hum Genet, 2004, 74(3):558-563.
  • 4Liu P, Wakamiya M, Shea M J, et al. Requirement for Wnt3 in vertebrate axis formation[J]. Nat Genet, 1999, 22(4):361-365.
  • 5Koop D, Holland ND, Semon M, ct al. Retinoic acid signaling targets Hox genes during the amphioxus gastrula stage: Insights into early anterior-posterior patterning of the chordate body plan [J]. Dev Biol, 2010, 338(1):98-106.
  • 6Zhao X, Duester G. Effect of retinoic acid signaling on Wnt/be- ta-catenin and FGF signaling during body axis extension[J]. Gene Expr Patterns, 2009, 9 (6):430-435.
  • 7van Amerongen R, Berns A. Knockout mouse models to study Wnt signal transduction[J]. Trends Genet, 2006, 22(12):678- 689.
  • 8Bachler M, Neubuser A. Expression of members of the Fgf fam- ily and their receptors during midfacial development[J]. Mech Dev, 2001, 100(2) :313-316.
  • 9Rice R, Spencer-Dene B, Connor EC, et al. Disruption of Fgf10/ Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate[J]. J Clin Invest, 2004, 113(12) : 1692-1700.
  • 10Pomtaveetus T, Oommen S, Sharpe PT, et al. Expression of Fgf signalling pathway related genes during palatal rugae develop- ment in the mouse[J]. Gene Expr Patterns, 2010, 10(4/5):193- 198.

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中国医药导报
2013年 第30期

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