摘要
目的探讨曲安奈德对溃疡性直肠炎患者白细胞介素4和高迁移率族蛋白B1的影响。方法选择2011年6月～2012年10月四川省南充市中心医院治疗的40例溃疡性直肠炎患者，将其随机分为两组，观察组应用曲安奈德＋甲硝唑灌肠．对照组采用甲硝唑灌肠。观察两组治疗后7d的临床症状缓解情况，并对白细胞介素4和高迁移率族蛋白B1进行检测及对比。结果观察组临床症状缓解情况明显好于对照组，观察组治疗后7d的血清高迁移率族蛋白Bl水平[（2．17±0．19）μg／L]低于对照组[（3．36±0．38）μg/L]，自细胞介素4水平[（31．32±3．58）ng／L]高于对照组[（24．75±2．73）ng／L]，差异均有统计学意义（P〈0．05）。结论曲安奈德灌肠可缓解患者临床症状，其可能机制是降低高迁移率族蛋白B1的表达同时上调白细胞介素4的表达，从而起到抗炎性反应的作用。
Objective To study the influence of Triamcinolone Acetonide for the expression of intedeukin-4 and high mobility group boxlprotein of patients with proctitis ulcerosa. Methods Forty proctitis ulcerosa patients in Nanchong Central Hospital from June 2011 to October 2012 were randomly divided into two groups, observation group were treated with Triamcinolone Acetonide and Metronidazole, and control group were treated with Metronidazole, then clinical effects and the indexes of in- terleukin-4 and high mobility group boxlprotein after treatment at seventh day were detected and compared. Results The clinlcal symptoms relieve of observation group was better than that of the control group, the high mobility group boxlprotein of observation group after treatment at seventh day [（2.17±0.19） μg/L] were all lower than those of the control group [（3.36±0.38） μg/L], interleukin-4 was higher [（31.32±3.58） ng/L] than that of control group [（24.75±2.73） ng/L], there were all significant differences （P 〈 0.05）. Conclusion Triamcinolone Acetonide is effective in treating proctitis ulcerosa, its mechanism may be to reduce high mobility group boxlprotein level and raise intedeukin-4 level.
出处
《中国医药导报》
CAS
2013年第30期82-84,共3页
China Medical Herald
