生存素与三氧化二砷功能的相关性及其对肿瘤细胞凋亡的影响

Survivin correlating with arsenic trioxide and its impacts on apoptosis of tumor cells

生存素是迄今发现的作用最强的细胞凋亡抑制因子,在正常细胞中几乎不表达,而在多数肿瘤细胞中高表达,它与化疗的耐药性、肿瘤复发的增加、患者生存时间的缩短存在相关性,这种具有特异性的组织分布和特殊的作用机制使其成为癌症治疗的新靶标。三氧化二砷是中药砒霜的主要成分,具有1500余年应用历史。现代研究发现其对急性早幼粒细胞白血病具有优异疗效,且对各种肿瘤具有抑制细胞增殖并诱导凋亡的作用。生存素和三氧化二砷在癌症和血液病治疗方面的前景值得关注,本文就细胞凋亡、血管重塑和耐药性三方面探讨两者功能的相关性。

Survivin, the strongest inhibitor of apoptosis found so far, barely expressed in normal cells, while highly expressed in most cancer cells, related with chemotherapy resistance, increased tumor recurrence, and shortened patient survival. Because of its specific tissue distribution and paticular mechanism of action, it has been thought as a new strategy for cancer treatment. Arsenic trioxide is the main component of white arsenic, which is a kind of traditional Chinese materia medica applied for about 1500 years. Modern studies have found out its outstanding efficacy for acute promyelocytic leukemia, besides, it can inhibit tumor cell proliferation and induce apoptosis of various tumors. The prospect of survivin and arsenic trioxide in treating cancer and blood disease is worth concern, in this review, we try to discuss the correlation of survivin and arsenic trioxide in three aspects：apoptosis, vascular remodeling and multidrug resistance.