原位傅立叶变换红外光谱在有机合成研究中的应用

Application of in situ Fourier transform infrared spectroscopy to research of organic synthesis

实时在线原位红外光谱技术以傅立叶变换红外光谱(FTIR)原理为基础,能精确监测反应中重要组分的浓度变化,由于光谱吸收直接与物质浓度相关,通过组分的浓度变化趋势,可以确定关键的反应参数,推断反应机制和反应路径,分析和验证反应动力学,为研究反应动力学和反应机制提供重要信息。因此,FTIR已广泛用于有机合成反应机制和反应动力学的研究以及晶型研究中,为药物研究中高效的合成目标化合物,减少副产物的生成以获得高质量的产品提供了重要的研究工具。本文对近5年来FTIR在有机合成中的应用进行综述。

In situ Fourier transform infrared spectroscopy（FFIR） has the ability to accurately detect the change in concentration of important components in chemical reactions via the utilization of mid infra-red spectrum. Based on the principle that spectral absorption is directly related to concentration, in situ FTIR is able to confirm important response parameter, identify the reaction mechanisms and reaction paths, analyze and verify reaction kinetics from the trend of changes in concentrations of components. In this way, the technology provides crucial information on reaction kinetics and reaction mechanisms. In situ FFIR is now widely used in the research of mechanism of organic synthesis, reaction dynamics and crystallization process. It is a very useful tool to synthesize the target compound effectively, reduce the production of side products and get high quality products in the research of drug synthesis. This article reviews the use of in situ FFIR in the research of drug synthesis in the last five years.