男性2型糖尿病患者25羟基维生素D的水平变化及与骨密度的关系

Relationship between the change of 25-hydroxyvitamin D level and bone mineral density in type 2 diabetes male patients

目的探讨男性2型糖尿病（type2diabetesmellitus，T2DM）患者血清25羟基维生素D[25．（OH）D3]水平的变化，以及25一（OH）D3水平与骨密度（bonemineraldensity，BMD）的关系。方法87例男性T2DM患者为病例组，均行腰椎及髋部双能X线骨密度测定，同期男性健康体检者90名为正常对照组。用酶联免疫法检测各组25-（OH）D3水平及相关临床和生化指标。比较两组25-（OH）D3的水平以及25-（0H）D3与男性病例组BMD的相关性。结果①病例组25-（OH）D3水平为（10±4）ngZml，对照组为（12±4）ng／ml，T2DM组25-（OH）D3明显低于对照组（P〈0．05）。②病例组骨质疏松症（osteoporosis，OP）患者25-（OH）D3为（10±3）ng／ml，无OP患者为（9±4）ngZml，两组比较差异无统计学意义（P〉0．05）。结论男性2型糖尿病患者25-（OH）D3水平明显降低，25-（OH）D3与骨密度无明显相关性。

Objective To investigate the serum changes of 25-hydroxyvitamin D level in the male patients with type 2 diabetes, and the relationships between 25-hydroxyvitamin D level and bone mineral density. Methods Eighty-seven male patients with type 2 diabetes mellitus were selected as the case group, and 90 male healthy people were selected as the control group. ELISA were used for the de- tection of serum 25-hydroxyvitamin D, relevant clinical and biochemical index were also detected. Then the serum differences of 25-hydroxyvitamin D levels in the two groups were contrasted and the relationship between 25-hydroxyvitamin D and the T2DM male patients was analyzed. Results （.if）Serum 25- hydroxyvitamin D level of T2DM group was significantly lower than that of the control group（ P 〈0. 05 ）. （2）There was no significant difference in serum 25-hydroxyvitamin D level between osteoporosis patients group and no osteoporosis patients group in T2DM group （P 〉 0.05 ）. Conclusions Serum 25- hydroxyvitamin D level in male patients with type 2 diabetes was significantly lower than that of control group. No correlation was found between serum 25-hydroxyvitamin D level and bone mineral density in male patients with type 2 diabetes.