早期应用黛力新干预脑卒中后抑郁临床疗效观察

Clinical effect observations of early use Dailixin for post-stroke depression

目的观察早期应用黛力新干预脑卒中后抑郁的临床疗效。方法将120例符合诊断标准及排除标准的脑卒中后抑郁患者分为两组，常规治疗基础上，黛力新组给予口服黛力新l片／d。两组患者治疗前、治疗后2周和治疗后4周分别进行汉密织顿抑郁量表（HAMD）和神经功能抽损评分（NIHSS），评价患者的抑郁及神经功能恢复情况。结果服用黛力新的患者抑郁状态和神经功能明显改善，与对照组相比，其治疗后2周、治疗后4周HAMD和NIHSS评分比较差异有统计学意义（P〈0．05）。结论早期应用黛力新治疗可干预脑卒中患者的抑郁状态，并促进患者神经功能恢复。

Objective To observe the clinical effect of early use Dailixin for post-stroke depres- sion. Methods One hundred and twenty patients with post-stroke depression who were according with choosing and removing conditions were randomly divided into two groups, with 60 cases in each group. The patients in treatment group were treated by Dailixin based on regular cure. Hamilton depression rat- ing scale（ HAMD） and National Institute of Health stroke scale （NIHSS） were assessed before treatment and after two weeks, four weeks treatment. Results After two weeks, four weeks treatment, depression condition and nerve function of Dailixin group improved. HAMD and NIHSS score of the treatment group was better than that of control group（ P 〈 0.05 ）. Conclusions Early use Dailixin treatment after stroke may interfere with depression conditions and can improve the nerve functional recovery of patients.