黄芪精口服液联合硫辛酸预防奥沙利铂所致神经毒性疗效观察

Clinical Study of the Protective Effect of Thioctic Acid Combined with Huangqi Oral Liquid on Oxaliplatin-induced Neurotoxicity

目的:观察黄芪精口服液联合硫辛酸对奥沙利铂引起的神经毒性的预防作用。方法:将接受含奥沙利铂方案化疗的70例恶性胃肠道肿瘤患者按照随机数字表法分为预防组35例和对照组35例。对照组采用单纯化疗,预防组于化疗的前3天起每日给予硫辛酸注射液20 mL,静脉滴注,同时口服黄芪精口服液10 mL,每日2次,至化疗结束。观察八个周期化疗结束后两组的神经毒性发生率、发生程度和化疗前后外周神经传导速度。结果:化疗后预防组神经毒性发生率明显低于对照组,差异具有统计学意义(P<0.05),两组患者正中神经和腓总神经传导速度均减慢,比对照组减慢更明显,差异具有统计学意义(P<0.05)。结论:黄芪精口服液联合硫辛酸对奥沙利铂引起的神经毒性具有一定的预防作用。

Objective： To explore the protective effect of Thioctic acid combined with Huangqi oral liquid on Oxaliplatin-induced neurotoxicity.Methods： 70 Patients with malignant gastroenteric tumor were randomly divided into prevention group and control group,35 cases in each group.The prevention group was given Thioctic acid injection 20 mL,intravenous drip and Huangqijing oral liquid 10 mL,2 times daily to the end of chemotherapy.Observe the incidence rate,degree and nerve conductive velocity after eight cycles.Results： After eight cycles of chemotherapy,the incidence and severity of Oxaliplatin-induced neurotoxicity of treatment group was lower than that of control group（P 0.05）.The nerve conduction velocity of median nerve and peroneal of the two groups stepped down,especially the control group（P 0.05）.Conclusion： The Thioctic acid combined with Huangqi oral liquid has protective effect on Oxaliplatin-induced neurotoxicity.