45株金黄色葡萄球菌的药敏结果分析

Analysis of results of drug susceptibility test for 45 strains of Staphylococcus aureus

目的了解金黄色葡萄球菌对抗生素的敏感性,为临床合理治疗提供科学依据。方法使用梅里埃公司的VITEK 2 Compact全自动细菌鉴定/药敏仪进行细菌分离鉴定和对12种抗生素作药敏试验。结果金黄色葡萄球菌对万古霉素和利奈唑胺的敏感性最高,达到100%;对莫西沙星、复方新诺明的敏感率>50%,对左氧氟沙星、环丙沙星的敏感率>40%,对苯唑西林、四环素、庆大霉素、克林霉素、红霉素及青霉素的敏感率<40%,耐药性较强。结论万古霉素成为治疗金黄色葡萄球菌的首选药物,但其价格较高,连续用药有较高风险,利奈唑胺副作用小,临床疗效显著,可用来替代万古霉素。

Objective To learn the susceptibility of Staphylococcus aureus to antibiotics and provide scientific basis for clinical rational treatment. Methods Drug susceptibility test was conducted in 12 antibiotics and isolation and iden- tification of bacteria used by VITEK 2 Compact automatic bacteria identification/drug susceptibility instrument from BioM6rieux company. Results The susceptibility of Staphylococcus aureus to vaneomyein and liuezolid was the highest and it was up to 100%;the susceptibility rate to moxifloxacin and TMP-SMZ was above 50%,to levofloxacin and eiprofloxacin was above 40%,to oxacillin,tetraycline,gentamycin,clindamycin,erythromycin as well as penicilin was be- low 40%,the drug tolerance of staphylococcus aureus was relatively strong. Conclusion Vancomycin becomes the first choice drug in the treatment of Staphylococcus aureus,its price is relatively high,and higher risk is present when the drug is continuously used,linezolid has less side effect and significant clinical efficacy,and it can be used to replace vancomycin.