安巢驻宫饮联合孕三烯酮治疗子宫内膜异位症术后的临床观察

Clinical observation of An chao zhu gong yin combined with gestrinone treating endometriosis post-operation

目的观察安巢驻宫饮联合孕三烯酮治疗子宫内膜异位症术后的临床效果。方法选择2010年7月前入组行子宫内膜异位症术后的患者312例,随机分为中医治疗组92例、中西医结合组102例、西医对照组118例。比较3组的疗效、复发及妊娠情况。结果随访3年,3组的总有效率比较,差异无统计学意义(P>0.05);中西医结合组的复发率低于西医对照组(χ2=5.4179,P<0.05)且低于中医治疗组(χ2=4.2358,P<0.05),中医治疗组与西医对照组比较,差异无统计学意义(χ2=0.0253,P>0.05);3组术后1年内的妊娠率比较,差异无统计学意义,3年后,中西医结合组的总妊娠率高于西医对照组(χ2=19.9948,P<0.01),且高于中医治疗组(χ2=11.5244,P<0.01),中医治疗组与西医对照组比较,差异无统计学意义(χ2=0.7691,P>0.05)。结论安巢驻宫饮联合孕三烯酮治疗子宫内膜异位症术后能够提高其妊娠率,降低复发率,减轻不良反应,适用于有生育要求的患者,值得临床应用以及进一步推广研究。

Objective To observe the clinical effect of An chao zhu gong yin combined with gestrinone treating endometriosis post-operation. Methods 312 cases with endometriosis post-operation were selected before July 2010 randomly divided into the treatment group with traditional Chinese medicine （n=92）,the group with integrated traditional chinese and western medicine （n=102）,the control group with western medicine （n=118）.The curative effect,recurrence and pregnancy of the three groups were compared. Results All patients were followed-up for 3 years,there was no statistical difference of the total effective rate in three groups （P〉0.05）;the recurrence rate of the group with integrated traditional chinese and western medicine was lower than that in the the control group with western medicine （x^2= 5.4179,P〈0.05） and the treatment group with traditional Chinese medicine （x^2=4.2358,P〈0.05）,there was no statistical difference of recurrence rate between the treatment group with traditional Chinese medicine and the control group with western mdeicinc （X2=0.0253 ,P〉0.O5）;after 3 years,the total pregnancy rate of the group with integrated traditional chinese and western medicine was higher that in the control group with western medicine （x^2=19.9948,P〈0.01） and the control group with traditional Chinese medicine （x^2=ll.5244,P〈0.01）,there was no statistical difference between the treatment group with traditional Chinese medicine and the control group with western mdeicine （x^2=0.7691,P〉 0.05）. Conclusion Treating endometriosis post-operation uesd by n chao zhu gong yin combined with gestrinone can improve pregnancy rate,reduce the recurrence rate,reduce adverse reactions,and it is especially suitable for patients with breed requirement.h is worthy of clinical application and deserved further research.