初治慢性粒细胞白血病中PTEN、BMI-1、BCR-ABL与Sokal分期的相关性研究

Study on the correlation between Sokal staging and PTEN,BMI-1, BCR-ABL gene expression in initial chronic myeloid leukemia

通过荧光定量PCR检测不同分期慢性粒细胞白血病(CML)患者骨髓中PTEN、BMI-1、BCR-ABL的表达量,分析Sokal分期与基因表达的相关性。结果显示按照Sokal分期分为高危组、中危组及低危组,BMI-1、PTEN、BCR-ABL 3个基因的表达水平在3组间比较差异无统计学意义。表明CML患者预后相关基因表达与Sokal分期之间无相关性。

To use the real-time PCR to detect the expression of FFEN, BMI-1 ,BCR-ABL of 73 cases chronic myeloid leukemia in different stages, and analyze the dependency between the staging and expression. Results showed the expression of BMI-1, PTEN, BCR-ABL in different stages following Sokal is no statistical significance with stage. It indicates that there is no statistical significance between the expression of PTEN, BMI-1, BCR-ABL and Sokal stage.