地西泮联合小剂量奥氮平治疗酒依赖126例临床观察

THE CLINICAL EFFECT OF DIAZEPAM COMBINATION WITH SMALL DOSE OF OLANZAPINE ON TREATMENT OF ALCOHOL DEPENDENCE

目的:探讨地西泮联合小剂量奥氮平治疗酒精依赖的疗效。方法:对2010年3月-2012年3月入住山东省安康医院的126例酒依赖、酒精所致精神障碍、酒精戒断综合征患者的病例资料进行回顾性分析。分析患者抑郁自评量表、酒精戒断综合征评定量表(AWS)评定疗效的数据结果。结果:(1)地西泮联合小剂量奥氮平治疗酒精戒断综合征评定量表在治疗d3、5、7的评分均显著降低。(2)抑郁自评量表于入院d1及治疗1周比较,差异有显著性意义。结论:(1)长期大量嗜酒对患者心理及躯体均有明显的损害,及早给予医学干预和系统治疗十分必要。(2)奥氮平为非典型抗精神病药物,与地西泮联合使用兼有情感稳定剂作用,对酒精性精神病治疗有效,且使用安全、不良反应少。

Objective： To study the clinical curative effect of diazepam combination with small dose of olanzapine on treatment of alcohol dependence. Metds ： The clinical data of 126 patients who suffered from alcohol dependence were retrospectively analyzed ,including mental disorders due to use of alcohol and the alcohol withdrawal syndrome from March 2010 to March 2012 in Ankang hospital of Shandong province. The data of self rating depressive scale, the scale for assessment of alcohol withdrawal syndrome （AWS） was analyzed. Resu （ 1 ） The scores of AWS were decreased significantly at the day 3,5,7 after treatment with diazepam combination with small dose of olanzapine. （2）There was a significant difference between the first day and 1 week after treatment in self rating of depressive scale. Conclusion：（ 1 ）The psychological and physiological state are obviously damaged after drinking a large amount for a long time, and early medical intervention and systematic treatment are necessary. （2） Olanzapine is an atypical antipsychotic drug, and plays a role in the treatment of alcoholic psychosis combined with diazepam as a mood stabilizer. Additionally, this combination is safe and has less adverse reactions.