Aurora A激酶在软骨肉瘤中的表达及意义

Expression and significance of Aurora Kinase A in chondrosarcoma

目的检测Aurora A激酶在软骨肉瘤组织中的表达情况,并进一步探讨其与软骨肉瘤各临床病理特征的关系及将其作为软骨肉瘤新的分子治疗靶点的可能性。方法采用免疫组化SP法,检测软骨肉瘤(70例)和软骨瘤(40例)组织中Aurora A激酶的表达,评价Aurora A激酶的表达与软骨肉瘤临床病理参数的关系。结果 Aurora A激酶在软骨肉瘤中的阳性表达率明显高于软骨瘤,差异有统计学意义(P<0.01);Aurora A激酶在普通型软骨肉瘤低级别组的表达低于中高级别组的表达,差异有统计学意义(P<0.01);Aurora A激酶软骨肉瘤复发组和非复发组以及转移组和非转移组中的表达差异有统计相关性(P<0.05),与年龄、性别等临床参数无统计相关性(P>0.05)。结论 Aurora A激酶在软骨肉瘤组织中的表达明显高于在软骨瘤中的表达,可能通过某种机制参与了软骨肉瘤的发生及侵袭和转移的过程,且与临床病理特征有相关性;检测Aurora A激酶的阳性表达有助于判断软骨肉瘤的恶性程度及有可能将其作为软骨肉瘤的分子治疗靶点。

Objective： To test the expression of Aurora Kinase A in chondrosarcoma and the relationship of its clinical and pathologic features of chondrosarcoma and the potential of considering Aurora Kinase A as a new molecular target against chondrosarcoma. Methods： The expression of Aurora Kinase A in chondrosarcoma （70 specimens） and chondroma （40 specimens） were tested by immunohistochemistry and the relationship of its clinical and pathologic features of chondrosarcoma was investigated. Results： The expression of Aurora Kinase A in chondrosarcoma group was obviously higher than that in ehondroma group （P 〈 0.01 ）. The expression of Aurora Kinase A in common chondrosarcoma of low class group was lower than that in middle and high class groups （ P 〈 0. 01 ） ; The expression of Aurora Kinase A in chondrosarcoma was quite different between reoccurring group and non reoccurring group, as well as in metastasis group and non metastasis group（ P 〈 0. 05 ）. However, no correlation with other clinical and pathologic features was observed. Conclusion： The expression of Aurora Kinase A in chondrosareoma group is obviously higher than that in the chondroma group, and it has significant correlation with the clinical and pathologic features. Aurora Kinase A may play an important role in the process of occurrence, progression and metastasis of chondrosarcoma and Aurora Kinase A can serve as a new prognosis marker and molecular target against chondrosarcoma.