青蒿素-β-环糊精包合物的制备及表征

Preparation and Characterization of Inclusion Complex Arteannuin with β-Cyclodextrin

研究青蒿素-β-环糊精包合物的制备与性质,通过相溶解度法、红外光谱(IR)对其包合物进行表征.结果表明,β-环糊精可增加青蒿素的溶解度;相溶解度法测定青蒿素与β-环糊精的包合常数为77.44L/mol;IR检测到青蒿素的特征吸收峰,受包合物形成的影响其强度降低、峰形变宽、发生位移或消失等现象,青蒿素与β-环糊精可以形成稳定的包合物.

The preparation and characterizations of the inclusion complex of arteannuin（ART） with β-cyclodextrin（β-CD） were investigated.The properties of arteannuin with β-cyclodextrin were characterized and analyzed by phase solubility analysis and infrared spectrography（IR）.Results showed that β-cylcodextrin could increase the solubility of arteannuin;the inclusion constants of arteannuin with β-cylcodextrin（β-CD） was calculated as 77.44L / mol;IR spectra showed that the intensity of a few characteristic absorption peak of ART decreased,the peak shape was widened and the displacement changed or disappeared under the influence of inclusion complex.It is concluded arteannuin and β-cylcodextrin can form stable inclusion complexes.