口腔癌中肿瘤出芽与VEGF-C表达及淋巴结转移的相关关系

The Relationship between Tumour Budding,VEGF-C Expression and Lymph Node Metastasis in Oral Carcinoma

目的:通过检测肿瘤出芽、淋巴结转移以及血管内皮生长因子-C(VEGF-C)表达水平,分析口腔癌中肿瘤出芽与VEGF-C表达及淋巴结转移的相关关系,为临床治疗提供理论参考。方法:选取2009年1月-2013年1月4年间在我院接受诊治且资料完整63例口腔癌患者作为研究对象,观察肿瘤出芽、VEGF-C表达和淋巴结转移情况,分析相互之间的相关关系。结果:本次纳入研究的患者中,检出肿瘤出芽患者40例,所占比例为63.5%,VEGF-C表达阳性患者39例,阳性率率为61.9%,淋巴结转移患者40例,转移率为63.5%;肿瘤出芽与淋巴结转移的符合率为84.1%,肿瘤出芽与VEGF-C的表达符合率为79.4%,VEGF-C的表达与淋巴结转移发生的符合率为76.2%。肿瘤出芽与淋巴结转移呈正相关,经Spear相关分析,r=0.932,P<0.05,与VEGF-C的表达也呈正相关,经Spear相关分析,r=0.897,P<0.05。结论:肿瘤出芽与VEGF-C的表达水平和淋巴结转移均呈正相关关系,可用于预测判断口腔癌淋巴结转移情况。

Objective： To analysis the relation of tumour budding, VEGF-C expression and lymph node metastasis by detection tumour budding, lymph node metastasis and vascular endothelial growth factor C （VEGF - C） expression level in oral carcinoma, and provide reference for clinical treatment. Methods： 63 cases of oral cancer patients who accept the diagnosis and treatment in our hospital between 2009.1 and 2013.1, and all the data integrity as the research object, to observe the tumor budding, VEGF-C expression and lymph node metastasis, and analysis of the relationship between each other. Results： The patients included in the study, the positive ratio of tumor budding, VEGF - C expression and lymph node metastasis was 40（63.5%）, 39（61.9%） and 40（63.5%）. The accuracy of tumor budding and lymph node metastasis was 84.1%, The accuracy of tumor budding and the expression of VEGF-C coincidence rate was 79.4%, The accuracy of the expression of VEGF-C with lymph node metastasis coincidence rate was 76.2%. Budding of tumor and lymph node metastasis were positively correlated, r = 0.932, and the expression of VEGF -C were positively correlated, r = 0.897. Tumour budding was positively correlated with lymph node metastasis or VEGF-C expression, r=0.932,P〈0.05 or F=0.897, P〈0.05. Conclusion： Tumour budding was positively correlated with lymph node metastasis and VEGF-C expression, and can be used to predict lymph node metastasis in oral carcinoma.