甲磺酸桂哌齐特对缺血再灌注脑损伤大鼠的保护作用

Protection effects of methanesulfonic acid cinepazideon on brain ischemia reperfusion in rats

目的:观察甲磺酸桂哌齐特对大鼠缺血性脑损伤保护作用。方法:线拴法建立大鼠大脑中动脉阻塞(MCAO)再灌注损伤模型,72只雄性SD大鼠随机分为6组:假手术组、模型组、甲磺酸桂哌齐特组(20、40、80 mg/kg)和马来酸桂哌齐特组,观察药物对脑缺血再灌注大鼠的血栓形成、血小板聚集、脑梗死体积和对脑组织病理形态学变化的影响。结果:与模型组比较,甲磺酸桂哌齐特(40、80 mg/kg)可减少缺血再灌后脑梗死体积,抑制血栓形成和血小板聚集(P<0.05);同时可减轻脑组织神经元核固缩、溶解和脑细胞肿胀。与马来酸桂哌齐特相比无明显差异。结论:甲磺酸桂哌齐特对局灶性脑缺血再灌注损伤有保护作用。

Objective：To observe the protective effect of methanesulfonic acid cinepazideon（CMI） on cerebral ischemia reperfusion injury in rats. Methods：The local cerebral ischemia/reperfusion model was established by intralnminal thread occlusion of the middle cerebral artery occlusion （MCAO） in rats. Seventy-two male SD rats were randomly divided into five groups：model group,sham group,CMI treatment group （20,40,80 mg/kg） and cinepazide maleate treatment group （40 mg/kg）. Thrombosis,platelet aggregation,the infraction volume and pathomorphological changes of brain tissue were observed in each group. Results：Compared with model group,CMI could reduce infract volume,thrombosis and inhibit platelet aggregation （P 〈 0.05）. Also it could reduce neurons karyopyknosis,dissolution and swelling of the brain cells. And the effects had no difference with cinepazide maleate. Conclusion：CMI has a marked neuroprotective effect on local cerebral ischemia reperfusion injury in rats.