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N-甲基D-天冬氨酸受体NR2B亚基与学习记忆关系研究进展 被引量：1

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摘要 中枢神经系统N-甲基D-天冬氨酸受体(NMDAR)主要分布于中枢神经系统突触后膜等部位,对学习记忆的发生发展起着重要作用。其中,NMDA受体NR2B亚基在记忆的产生与维持及对记忆障碍的治疗有着深刻的意义。研究发现,NR2B亚基既可通过参与长时程增强(LTP)对学习记忆产生促进作用,亦可通过介导兴奋性氨基酸毒性作用导致神经功能损害,引起学习记忆障碍。故本文就NMDA受体NR2B亚基的分布、结构、功能及其与学习记忆的关系做一综述。
作者 何焰鹏 刘国荣 王宝军 梁芙茹 邹春燕
机构地区 内蒙古科技大学包头医学院 包头市中心医院
出处 《国际神经病学神经外科学杂志》 2013年第4期338-341,共4页 Journal of International Neurology and Neurosurgery
关键词 N-甲基-D-天冬氨酸受体 NR2B亚基 学习记忆
分类号 R338 [医药卫生—人体生理学]
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国际神经病学神经外科学杂志
2013年 第4期

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