声学组织定量技术定量诊断肝硬化的初步探讨

Preliminary study on the quantitative diagnosis of liver cirrhosis by acoustic structure quantification technology

目的初步探讨声学组织定量技术在肝硬化病变定量诊断中的应用价值。方法使用声学组织定量技术对120例健康志愿者(正常对照组)和90例肝硬化患者(肝硬化组)进行检查,分析其肝实质的超声原始回波信号,记录并比较其χ2值直方图和相关参数,包括红色曲线众数、红色曲线均值、红色曲线标准差、蓝色曲线众数、蓝色曲线均值、蓝色曲线标准差及蓝色曲线下面积与红色曲线下面积之比。结果正常对照组肝脏特点表现为回声较均匀,中等或中等偏低回声为主;肝硬化组肝脏特点表现为肝内回声杂乱,各类回声信号交织在一起。两组间红色曲线众数值比较差异无统计学意义,其余各参数比较差异均有统计学意义(P﹤0.05)。结论声学组织定量技术是一项非侵入性的检测肝硬化病变的新技术,具有无创、准确、客观等优点,在肝硬化病变定量诊断中有潜在的应用前景。

Objective To explore the application value of acoustic structure quantification （ASQ） technology on the quantitative diagnosis of liver cirrhosis.Method One hundred and twenty healthy volunteers （control group） and 90 patients with liver cirrhosis （liver cirrhosis group） were examined by ASQ technology. The original ultrasonic echo signal of the liver parenchyma was analyzed.The chi-square value and relevant parameters （Mode, Average, SD and BR Ratio） were recorded and comparative analyzed.Results The ultrasonography of control group was homogeneous and mainly showed medium or slightly low echo. However, the echogenicity of liver cirrhosis group was mixed and disorderly. No significant difference in mode value of red curve was found between the two groups,but significant differences in the rest parameters were found between them （P 〈 0.05）. Conclusion ASQ technology is a new techonlogy for the detection of liver cirrhosis with advantages of noninvasiveness, accuracy and objectivity, and it has potential application prospects in the quantitative assessment of liver cirrhosis.