EV71病毒感染动物模型研究进展

Advances in establishment of enterovirus 71 infection animal models

人肠道病毒71型(enterovirus 71,EV71)是引起手足口病的主要病毒之一,并可导致严重的神经系统疾病,近年随着发病率的升高,严重威胁了婴幼儿的生命健康。可感染EV71的动物模型是研究其致病机理、疫苗评价和药物研发等的重要工具,然而目前尚未建立有效的EV71感染标准化动物模型。本文将对不同物种的EV71病毒感染模型进行总结,并着重就利用基因修饰手段建立的EV71病毒感染模型进行讨论和展望。

Hand foot and mouth disease （HFMD） is caused by enterovirus family, in which enterovirus 71 （EV71） is the most common pathogen. Serious cases lead to neurological sympotoms and even death, especially in infants. A good EV71 infection animal model will not only help to study the mechanism of pathogenesis, and will also become an effective tool for developing vaccines and treatments. Here we review the advances in establishment of animal models of EV71 infection in different species, and further focus on status and prospects of EV71 infection models established by genetical modification.