肝肺综合征病理发生机制的研究进展

Research progress in the pathogenesis of hepatopulmonary syndrome

肝肺综合征(hepatopulmonary syndrome,HPS)是各种急慢性肝病的严重并发症,以肺微血管扩张引起的低氧血症为典型的病理改变。HPS的病理发生机制复杂,文中对肺微血管扩张、肠源性内毒素血症和肺内单核/巨噬细胞的聚集及血管新生在HPS发病机制方面的作用进行综述,期望通过对HPS病理发生机制的进一步了解,为HPS的防治提供新的思路和理论指导。

Hepatopulmonary syndrome （HPS） is one of the serious complications of acute or chronic liver diseases, which is characterized by pulmonary microvascular dilatation-induced hypoxemia. The pathogenesis of HPS is complicated, and this article pres ents an overview on the role of pulmonary microvascular dilatation, intestinal endotoxemia, activation of the lung monocyte/macrophage system, and angiogenesis in the pathogenesis of HPS. This study aimed to offer some new ideas and theoretical guides for the prevention and treatment of HPS through a deeper insight into the pathogenesis of hepatopulmonary syndrome .