1Fleming A.A British Medical Association Lecture ON VACCINE THERAPY IN REGARD TO GENERAL PRACTICE [J]. Br Med J, 1921,1 (3138 ) :255-259.
2Dubos RJ. STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS : I. PREPARATION OF THE AGENT. ITS ACTIVITY IN VITRO [J].J Exp Med, 1939,70 ( 1 ) : 1-10.
3Steiner H, Hultmark D, Engstrom A, et al.Sequence and specificity of two antibacterial proteins involved in'insect immunity[J] .Nature, 1981,292(5820) : 246-248.
4Schutte BC,Mitros JP,Bartlett JA,et al.Discovery of five conserved beta -defensin gene clusters using a computational search strategy [J].Proc Natl Acad Sci U S A,2002,99(4): 2129-2133.
5Yamasaki K,Schauber J,Coda A,et al.Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin [ J ] .FASEB J, 2006,20 (12) : 2068-2080.
6Nakatsuji T,Gallo RL.Antimicrobial peptides: old molecules with new ideas[J].J Invest Dermatol,2012,132(3 Pt 2):887- 895.
7Khandelia H,Ipsen JH,Mouritsen OG.The impact of peptides on lipid membranes [J].Biochim Biojphys Acta,2008,1778 (7- 8) : 1528-1536.
8Brogden KA.Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria[J ] ? Nat Rev Microbiol, 2005,3 (3) : 238- 250.
9Del CF,Del CI,Moreno F.Construction and characterization of mutations at codon 751 of the Escherichia coli gyrB gene that confer resistance to the antimierobial peptide microcin B17 and alter the activity of DNA gyrase [J].J Bacteriol, 2001,183 (6): 2137-2140.
10Nan YH,Park KH,Park Y,et al.Investigating the effects of positive charge and hydrophobicity on the cell selectivity, mechanism of action and anti-inflammatory activity of a Trp- rich antimicrobial peptide indolicidin[J].FEMS Microbiol Lett, 2009,292( 1 ) : 134-140.
6REDDY K V, YEDERY R D, ARANHA C. Antimicrobial peptides : premises and promises[J ]. Int J Antimicrob Agents, 2004, 24(6) : 536 -547.
7TAM J P,LU Y A,YANG J L, et al. An unusual structural motif of antimicrobial peptides containing end - to - end macrocycle and cystineknot disulfides [ J]. Proc Natl Acad Sci USA, 1999, 96 (6) : 8913 -8918.
8HO S N, HUNT H D, HORTON R M,et al. Site - directed mutagenesis by overlap extension using the polymerase chain reaction [J]. Gene, 1989, 77(1) : 51 -59.
9SCHAGGER H, VON J G. Tricine - sodium dodecyl sulfate - polyacrylamide gel electrophoresis for the Separation of proteins in the range from 1 to 100 ku [J]. Anal Biochem,1987,166(2) :368 - 379.
10MACAULEY - PATRICK S,FAZEND M L,McNEIL B, et al. Heterologous protein production using the Pichia pastoris expression system [J]. Yeast, 2005, 22(4) : 249 -270.
