新疆部分地区儿童复发性喉乳头状瘤HPV6和HPV11病毒感染在维吾尔族及汉族患者之间的差异

The different experession of human papilloma viral types 6and 11in uyghur and chinese juvenile recurrent respiratory papillomatosis in a large pediatric population in Xinjiang

目的:研究新疆部分地区喉乳头状瘤病毒HPV6,HPV11在汉族及维吾尔族儿童复发性喉乳头状瘤(JRRP)患儿中的表达差异。方法:采用聚合酶链反应(PCR)技术对喉乳头状瘤组织中HPV11和HPV 6DNA进行定型分析,结合回顾性分析1996-01-2008-03期间在新疆医科大学第一附属医院耳鼻咽喉科连续收治的42例JRRP患者。结果:HPV6/11阳性检出率97.61%(41/42),HPV6阳性36.58%(41/15),HPV11阳性63.41%(41/26),HPV6阳性组中维族HPV6阳性53.33%(8/15),汉族HPV6阳性46.67%(7/15),HPV11阳性组中维族HPV11阳性65.38%(17/26),汉族HPV11阳性34.61%(9/26)。结论:新疆部分地区JRRP以HPV11,6感染为主,HPV11感染者占多数,HPV病毒类型与维汉间的发病率之间差异无统计学意义。

Objective：To investigate the Human papilloma viral types 6 and 11 in a large pediatric population in Xinjiang and the different expression in chinese and uyghur pediatric population. Method： Using polymerase chain reaction（PCR） ,we analyzed paraffin embedded tissue in 42 cases of juvenile Recurrent Respiratory Papillomatosis（JRRP）and determined the HPV types 6 and 11, and to correlate these results with retrospectively analysis about those cases who were consecutively treated in our ENT department, meanwhile we carry out a critical review of the literature of JRRP. Result：A total HPV infection positive rate was 97.61% （41/42）, and HPVll positive rate was 63.41%（41/26）,HPV6 positive rate was36.58% （41/15）. In uyghur patient HPV11 positive rate was 65.38%（17/26）, HPV6 positive rate was53. 33% （8/15）. in Chince patient HPV11 positive rate was 34.61G （9/26）, HPV6 positive rate was46.67 % （7/15）. Conclusion ：Juvenile laryngeal papilloma is associated with HPV11,HPV6 infection and we considered that HPV11 infection may be the important guideline of the evaluation of disease prognosis, but no statistical signtificance was determined in the patients of various ethnic groups in Xin jiang （P〈0.05）.