单硝酸异山梨酯联合丹红治疗277例老年不稳定型心绞痛的临床分析

Clinical analysis on Isosorbide mononitrate combined Danhong injection therapy for 277 elderly patients with unstable angina

目的了解单硝酸异山梨酯联合丹红治疗老年不稳定心绞痛的临床疗效,为该病的临床治疗提供有效疗法。方法采用单硝酸异山梨酯缓释片联合丹红注射液治疗277例老年不稳定心绞痛,与单用常规药物治疗的对照组220例进行比较。观察两组的心绞痛发作持续时间、发作频率、心电图检查ST段和NST段波等指标,并观察两组的疗效和药物不良反应。结果治疗组治疗后的总有效率为91.24%;治疗组的显效率和总有效率均显著高于对照组(均P<0.05)。对照组、治疗组治疗后的各项观察指标均显著低于组内治疗前(均P<0.05)。治疗组治疗后的持续时间、ST段波形显著低于对照组治疗后(均P<0.05)。治疗组的药物不良反应发生率为2.89%。结论采用丹红联合单硝酸异山梨酯治疗老年不稳定性心绞痛的临床疗效显著,安全可靠,有进一步临床推广应用的价值。

[ Objects ] To find out the efficacy of isosorbide mononitrate combined Danhong injection therapy for elderly patients with unstable angina; to provide an effective therapy for the clinical treatment of the disease. [Methods] 277 elderly unstable angina patients were treated with Isosorbide mononitrate sustained release tablets and Danhong injection, while 220 cases of the control group were treated with conventional drug therapy. The indica- tors included angina pectoris duration, attack frequency, ECG ST-segment, and NST-segment were observed, and the efficacy and adverse drug reactions in both groups were also observed. [ Results ] After treatment, the total effective rate was 91.24%; Markedly effective rate and total effective rate of the treatment group was significantly higher than that of the control group （P 〈0.05）. After treatment, all the observed indicators of the two groups were signifi- cantly lower than that of the same group before treatment （P 〈0.05）. After treatment, the duration and ST segment waveform of the treatment group were significantly lower than that of the control group after treatment （P 〈0.05）. The rate of adverse drug reactions in the treatment group was 2.89%. [ Conclusions ] The isosorbide mononitrate combined Danhong injection therapy for elderly patients with unstable angina was significantly effect, safe and reliable, and with a further clinical application value.