醌茜素荷移分光光度法测定盐酸伊托必利

Spectrophotometry Determination of Itopride Hydrochloride Based on Charge-transfer Reaction with Quinalizarin

目的建立测定盐酸伊托必利含量的方法。方法盐酸伊托必利与醌茜素在碱性条件下可发生电荷转移反应，形成稳定的1：1型荷移络合物，在最大吸收波长578nm处测定络合物的吸光度。结果盐酸伊托必利药物质量浓度在20．0～140．0mg·L-1。内服从比耳定律，相关系数为0．9991，RSD为0．62％，表观摩尔吸光系数为2．03×103L·mol-1．cm-1，回收率为99．1％～102．3％。结论方法准确、简便、快捷，可用于测定片剂中盐酸伊托必利的含量。

OBJECTIVE To establish a method for determination of itopride hydrochloride. METHODS Itopride hydrochloride reacted with quinalizarin to form stable charge transfer complex whose composition ratio is 1 ： 1 under alkaline conditions and could be determined at 578 nm. RESULTS Beer＇s Law is obeyed in the range of 20.0-140.0 mg L-1 of itopride hydrochloride and the correlation coefficient is 0.999 1. And RSD is 0.62%. The apparent molar absorptivity of the complex is 2.03×103 L.mol-1.cm-1. The recoveries are 99.1%-102.3%. CONCLUSION The method is simple, rapid and accurate, can be used to the determination of itopride hydrochloride in tablets.