孕妇血清中微量元素与新生儿体重的关系研究

Study on the relationship between maternal serum trace elements and neonatal birth weight

目的:探讨孕妇血清微量元素与新生儿体重的关系。方法:采用电感耦合等离子体质谱法(ICP-MS)对160名孕妇的孕早期、孕中期和孕晚期血清中Mg、Ca、Fe、Cu和Zn元素的含量进行追踪测定,随访并测定新生儿出生体重,分析孕晚期孕妇血清微量元素含量与新生儿体重的相关性。结果:孕妇在不同孕期血清中钙、铁、锌、铜和镁元素含量均在正常范围内。钙元素含量随着孕期的增加稍有降低,中期下降明显;铁、锌和镁元素随着孕期的增加显著降低;铜元素随着孕期的增加显著升高;孕晚期孕妇血清中钙>75 mg/L、铁>460 mg/L、锌>6.12 mg/L和镁>34 mg/L浓度有助于新生儿更高的出生体重。结论:不同孕期孕妇血清中微量元素水平发生了一定程度的改变,孕妇应根据不同孕周,合理补充适量钙、铁、锌和镁元素。

Objective： To explore the relationship between maternal serum trace elements and neonatal birth weight. Methods： The serum contents of magnesium, calcium, iron, copper, and zinc in 160 pregnant women were traced and detected by inductively couple plasma mass spectrometer （ ICP - MS） during the first, the second, and the third trimesters of pregnancy ; the neonatal birth weight was fol- lowed up and measured, the correlation between maternal serum trace elements contents and neonatal birth weight during the third trimester of pregnancy was analyzed. Results： The serum contents of calcium, iron, zinc, copper, and magnesium in pregnant women of different tri- mesters of pregnancy were within normal ranges. The content of calcium decreased slightly with increase of gestational weeks, the content of iron decreased significantly during the second trimester of pregnancy ; the contents of iron, zinc, and magnesium decreased significantly with increase of gestational weeks ; the content of copper increased significantly with increase of gestational weeks ; the contents of serum calcium, iron, zinc, and magnesium in pregnant women during the third trimester of pregnancy more than 75 mg/L, 460 rag/L, 6. 12 mg/L, and 34 mg/L respectively were helpful to increase neonatal birth weight. Conclusion ： The serum levels of trace elements in pregnant women of different trimesters of pregnancy change to a certain degree, the pregnant women should supplement calcium, iron, zinc, and magnesium rea- sonably according to gestational weeks.