阿奇霉素对支气管哮喘患儿外周血辅助性T淋巴细胞的影响

Effect of azithromycin on helper T lymphocytes in peripheral blood of children with bronchial asthma

目的:探讨阿奇霉素对支气管哮喘患儿外周血辅助性T淋巴细胞的影响及其临床应用价值。方法:选取支气管哮喘的患儿64例,按照随机数字表分为观察组和对照组,每组各32例。对照组给予常规治疗,观察组在对照组基础上给予阿奇霉素治疗,分别在治疗前、后对两组患儿外周血辅助性T淋巴细胞相关指标进行检测,观察对比两组检测结果。结果:两组患儿治疗后IFN-γ、IFN-γ/IL-4皆比治疗前明显升高(P<0.05),观察组升高幅度比对照组更为显著(P<0.05);两组患儿治疗后IL-4、IL-10皆比治疗前明显降低(P<0.05),观察组降低幅度比对照组更为显著(P<0.05)。结论:阿奇霉素干预对支气管哮喘患儿外周血辅助性T淋巴细胞有明显的影响,发挥出良好的免疫调节作用,能够促病情转归,具有重要的临床应用价值。

Objective： To explore the effect of azithromycin on helper T lymphocytes in peripheral blood of children with bronchial asthma and its clinical application value. Methods ： Sixty - four children with bronchial asthma were selected and divided into observation group and control group according to random number table, 32 children in each group. The children in control group were treated with routine therapy; the children in observation group were treated with routine therapy and azithromycin ; the related parameters of helper T lymphocytes in peripheral blood before and after treatment in the two groups were detected and compared. Results： The levels of interferon -γ （ IFN - γ）, IFN -γ interleukin - 4 （ IL - 4 ） after treatment in the two groups were statistically significantly higher than those before treatment （ P 〈 0. 05 ） , and the increasing amplitudes in observation group were statistically significantly higher than those in control group （ P 〈 0. 05 ） ; the levels of IL -4 and IL - 10 after treatment in the two groups were statistically significantly lower than those before treatment （P 〈 0. 05 ）, and the decreasing amplitudes in observation group were statistically significantly higher than those in control group （P 〈 0.05 ） . Conclusion： Azithromycin intervention has obvious impact on helper T lymphocytes in peripheral blood of children with bronchial asthma, which plays a good role in immunoregulation and recovery promotion, so its clinical application value is important.