摘要
目的:考察单硝酸异山梨酯注射液与米力农注射液的配伍稳定性。方法:将单硝酸异山梨酯注射液与米力农注射液按临床用药浓度分别溶于0.9%氯化钠注射液和5%葡萄糖注射液中,用高效液相色谱法测定配伍液在不同配伍时间的单硝酸异山梨酯和米力农的含量变化,同时考察配伍溶液的pH值、不溶性微粒数和外观。结果:在24 h内,两种药物配伍后含量、pH值无明显变化,不溶性微粒和外观性状符合要求。结论:单硝酸异山梨酯注射液和米力农注射液可以配伍使用,宜于24 h内输注完毕。
OBJECTIVE: To study the compatible stability of Isosorbide mononitrate injection and Milrinone injection. METH- ODS: lsosorbide mononitrate injection and Milrinone injection were dissolved into 0.9% Sodium chloride injection and 5% Glu- cose injection respectively. The contents of isosorbide mononitrate and milrinone in mixture were determined by HPLC at different time. pH value of the solution, the number and appearance of insoluble particle were also investigated. RESULTS: No significant change was noted in the contents of isosorbide mononitrate and milrinone and pH value within 24 h; the insoluble particle and ap- pearance of the mixture were in line with the requirements. CONCLUSIONS: The mixture of Isosorbide mononitrate injection and Milrinone injection can be used in compatibility, but it should be used up within 24 h after mixing.
出处
《中国药房》
CAS
CSCD
2013年第42期3984-3986,共3页
China Pharmacy