摘要
目的:了解某院药品不良反应(ADR)发生的特点及规律,为临床合理用药提供依据。方法:收集该院2007—2012年上报的561例ADR报告,按患者年龄、性别、给药途径、所涉及的药品种类、临床表现等进行统计分析。结果:ADR发生于各个年龄组,以21~60岁患者ADR报告位居首位,占60.96%(342例);女性(306例)较男性多(255例);以静脉给药的方式引发的ADR为主,占76.83%(431例);抗感染药引起的ADR最多,占总数的53.30%(299例);临床表现以皮肤及其附件损害最常见,占48.31%(271例)。结论:临床应重视ADR的监测工作,加强对患者用药过程观察,提高合理用药水平。
OBJECTIVE: To investigate the characteristics and pattern of adverse drug reactions (ADRs) in a hospital and pro- vide reference for rational drug use in the clinic. METHODS: 561 ADR reports collected from the hospital from 2007 to 2012 were analyzed statistically in respects of patients' age and sex, routes of administration, drugs types and clinical manifestations, etc. RE- SULTS: ADR occurred in every age groups. Among 561 ADR cases, the incidence rate of ADRs in the patients aged 21 to 60-year-old were higher than other age groups, occupying 60.96% (342 cases) ;female cases were more than male cases(306:255) ; intravenous drip was the main route of administration, accounting for 76.83% (431 cases) ; antibacterials occupied the highest pro- portion in ADRs, accounting for 53.30% (299 cases); lesions of skin and its appendants were the main clinical manifestations, oc- cupying 48.31% (271 cases). CONCLUSIONS: Great importance should be attached to ADR monitoring and medication observa- tion to improve the level of rational drug use.
出处
《中国药房》
CAS
CSCD
2013年第42期4001-4003,共3页
China Pharmacy
关键词
药品不良反应
分析
合理用药
Adverse drug reaction
Analysis
Rational drug use