原发性自发性气胸与炎症及肺纤维化相关因子的研究进展

h progress on primary spontaneous pneumothorax and related factors of inflammation and pulmonary fibrosis

原发性自发性气胸是胸外科常见急症，指肺实质或脏层胸膜在无外源性或介入性因素影响以及无基础性肺疾病条件下自行发生破裂，引起气体在胸膜腔蓄积，多见于青年男性。其具体发病机制目前尚不清楚，近年研究发现炎症及肺纤维化相关因子在其发生发展过程中起到了一定的作用，本文对这一方面的研究进展进行了总结和回顾。

Primary spontaneous pneumothorax （PSP） is common emergency in department of thoracic surgery. It is defined that the lung parenchyma or visceral pleura spontaneously ruptures in the absence of exogenous or interventional factors and underlying lung disease, causing the accumulation of gas in the pleural cavity. PSP typically occurs in young males. The exact pathogenesis of PSP is unknown. Some studies have found that the factors related to inflammation and pulmonar） fibrosis play a role in the development of PSP. This article reviews the research progress about it.